期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

受磷蛋白磷酸化位点Ser16在大鼠心力衰竭中的作用及机制 被引量：1

下载PDF
导出
摘要 心力衰竭是各种心脏疾病的终末阶段，研究心力衰竭的发生机制对该病的防治极其重要。心肌舒缩功能与肌浆网钙泵（SERCA2a）的活性密切相关，SERCA2a活性主要由受磷蛋白（PLB）调控，
作者 陈开祥 周新华 秦爱建
机构地区 江苏省连云港市第二人民医院急诊中心 扬州大学江苏省动物预防医学重点实验室
出处 《实用临床医药杂志》 CAS 2012年第24期5-7,10,共4页 Journal of Clinical Medicine in Practice
基金 连云港市卫生局科研项目(ZC315)
关键词 心力衰竭 受磷蛋白 大鼠H-89
分类号 R542.2 [医药卫生—心血管疾病]
  • 相关文献

参考文献10

  • 1Zarain-Herzberg A, Regulation of the sarcoplasmie reticulum Ca2 +-ATPase expression in the hyperrophic and failing heart [J]. Can J Physiol Pharmacol, 2006, 84(5): 509.
  • 2杜晓阳,谭武红,刘健,翟连榜,王立新,耿冬,蓝和楼,张振强.异丙基肾上腺素致豚鼠慢性心力衰竭模型的建立[J].西安交通大学学报（医学版）,2006,27(5):464-465. 被引量：3
  • 3Bouziane A M, Michel C, Catherine R M, et al. The Cy- tosolic Phospholipase A2 Pathway, a Safeguard of 132-Adren- ergic Cardiac Effects in Rat[J]. J Biol Chem. 2005, 280 (19): 18881.
  • 4Tsuyoshi Tsuji, Federica del Monte, Yoshiro Yoshikawa, et al. Rescue of Ca2 + overload- induced left ventriclur dysfunc- tion by targeted ablation of phospholam - ban [ J ]. Am J Physiol Heart Circ Physiol, 2009, 296(2) : H31.
  • 5陈开祥,祝宝华,刘晨,奚群英,张能锋,王金桂,于晓頔.缺氧预适应和前胡丙素预处理对心肌受磷蛋白磷酸化水平的影响[J].中华老年心脑血管病杂志,2008,10(3):210-213. 被引量：4
  • 6Yamada M, Ikeda Y, Yano M, et al. Inhibition of protein phosphatase 1 by inhibitor - 2 gene delivery ameliorates heart failure progression in genetic ardiomyopathy [ J ]. FASEB J, 2006, 20(8): 1197.
  • 7Zhang T, Guo T, Mishra S, et al. Phospholamban Ablation Rescues Sarcoplasmic Reticulum Ca2+ Handling but Exacer- bates Cardiac Dysfunction in CaMKIIC Transgenic Mice[ J ]. Circulation Research, 2010, 106(2) : 354.
  • 8Sun Y L, Hu S J, Wang I H, et al. Effect of beta- blockers on cardiac function and calcium handling protein in postinfarc- tion heart failure rats[J ]. Chest, 2005, 128(3) : 1812.
  • 9Soto D, Arcangelis V D, Zhang J, et al. Dynamic Protein Kinase A Activities Induc - ed by 13 - Adrenoceptors Dictate Signaling Propagation for Substrate Phosphory- lation and Myocyte Contraction [J ]. Circulation Research, 2009, 104 (6) : 770.
  • 10Quaile M P, Rossman E I, Berretta R M, et al. Reduced sarcoplasmic reticulum Ca2 + load mediates impaired contrac- tile reserve in right ventrieular pressure overload [J ]. J Mol Cell Cardiol, 2007, 43(5): 552.

二级参考文献21

  • 1陈开祥,祝宝华.缺氧预适应和前胡丙素对心肌细胞的保护作用及机制[J].实用临床医药杂志,2007,11(1):35-38. 被引量：9
  • 2Bers DM,Bridge JHB,Spritzer KW.Intracellar Ca^2+ transients during rapid cooling contractures in guinea-pig ventricular myocytes[J].J Physiol,1989,417(3):537-553.
  • 3西安医学院病理生理教研组.实验性心肌坏死的药物防治[J].西安医学院学报,1977,18(1):32-37.
  • 4杜晓阳 李广元 朱世英 等."心肌荣"对大鼠实验性心肌坏死防治的研究[J].中国地方病学杂志,1984,3(3):157-160.
  • 5杜晓阳 李广元 任瑛云 等.心荣口服液对异丙基肾上腺素引起大白鼠心肌坏死的保护作用[J].西安医科大学学报,1995,6:12-15.
  • 6Teerlink JR,Pfeffer JM,Pfeffer MA.Progressive ventricular remodeling in response to diffuse isoproternol-induced necrosis in rats[J].Cire Res,1994,75(1):105-113.
  • 7Manikandan P,Sumitra M,Kumar DA,et al.Antioxidant potential of a novel tetrapeptide derivative in isoproterenol-induced myocardial necrosis in rats[J].Pharmacology,2002,65 (2):103-109.
  • 8Suzuk M,Ohte N,Wang ZM,et al.Altered inotropic response of endothelin I in cardiomyocytes from rats with isoproterenol-induced cardiomypathy[J].Cardiovasc Res,1998,39 (3):589-599.
  • 9Yellon DM, Downey JM. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev, 2003,83:1113-1151.
  • 10Domenech RJ ,Sanchez G,Donoso P, et al. Effect of tachycardia on myocardial sareoplasmie retieulum and Ca^2+ dynamics:a mechanism for preconditioning? J Mol Cell Cardiol, 2003, 35:1429-1437.

共引文献5

同被引文献29

  • 1陈文为.从生物能学探讨中医”气”的实质[J].北京中医药大学学报,1994,17(2):7-9. 被引量：27
  • 2Van Bilsen M, Smeets P J, Gilde A J, et al. Metabolic remodeling of the failing heart: the cardiac bum - out syndrome [J]. Cardiovasc Res, 2004, 61(2): 21S.
  • 3John R, Ussher and Gary D, Lopaschuk. Clinical implications of energetic problems in cardiovascular disease[J]. Heart Metab, 2006,32: 9.
  • 4Taegtmeyer H. Cardiac metabolism as a target for the treatment of heart failure[J]. Circulation, 2004, 110(S): S94.
  • 5Ingwall J S. ATP and the heart[M]. USA: Kluwer Academic Publishers, 2002: 197.
  • 6T uunanen H, Knuuti J. Metabolic remodeling in human heart failure[J]. Cardiovasc Res, 2011, 90(2): 251.
  • 7Lopaschuk G D, belke D D, Gamble J, et al. Regulation of fatty acid oxidation in the mammalian heart in health and disease[J]. Biochim Biophys Acta, 1994, 1213(3): 263.
  • 8Weiss R G, Gerstenblith G, Bottomley P A. ATP flux through creatine kinase in the normal, stressed, and failing human heart[J]. Proc Natl Acad Sci USA, 2005, 102 (3) : SOS.
  • 9Neubauer S. The failing heart an engine out of fuel[J]. N Engl Med , 2007, 356(11): 1140.
  • 10Ellen Aasum. Myocardial Energetics And Efficiency [J]. Heart Metab, 2011, 53: 5.

引证文献1

实用临床医药杂志
2012年 第24期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部