摘要
目的评价芪参复康胶囊、氟西汀对重性抑郁症患者空间认知功能的影响。方法 48例重性抑郁症患者按随机数字表法分2组:中药组(n=24)给予芪参复康胶囊,西药组(n=24)给予氟西汀胶囊。两组患者于治疗前、治疗后6周进行17项HAMD评定及行视觉空间旋转任务的事件相关电位P500检查,26名健康志愿者(对照组)行P500检查。分析两组患者治疗前后对空间认知功能的影响。结果①两组治疗前HAMD评分比较差异无统计学意义[(29.4±6.4)分vs(29.6±5.5)分,P>0.05],治疗6周后中药组HAMD评分低于西药组[(11.6±4.1)分vs(13.7±4.3)分,P<0.05],HAMD减分率显著高于西药组[(61.5±6.3)%vs(53.7±6.1)%,P<0.05]。②两组治疗后P500潜伏期均较治疗前显著缩短,波幅均显著升高(P<0.05)。③治疗前两组患者P500潜伏期长于对照组(P<0.05),波幅低于对照组(P<0.05);治疗后中药组P500潜伏期、波幅均与对照组差异不显著(P>0.05),西药组P500潜伏期与对照组相近(P>0.05),波幅仍低于对照组(P<0.05)。结论芪参复康胶囊芪、氟西汀治疗可改善重性抑郁症视觉空间旋转认知功能,而短期内芪参复康胶囊提高患者空间旋转能力优于西药氟西汀。
Objective To compare the effects of Qishen Fukang capsules and fluoxetine on visuo-spatial cognitive function in major depressive disorder patients.Methods From January 2012 to May 2012,48 patients with major depressive disorder from Center for Mental Disease Control and Prevention of Third Hospital of PLA were enrolled and randomized into Qishen Fukang capsule group（Chinese medicine group,n=24） and fluoxetine group（Western medicine group,n=24） by the random number table.All patients were tested to make visuo-spatial rotation tasks in the brain event-related potential system and assessed with 17-item Hamilton depression scale（HAMD） before and after 6 weeks treatment.Another 26 healthy subjects（control group） were involved as controls and they were given simultaneously the same tests.And the effects of Qishen fukang capsules and Fluoxetine on visuo-spatial cognitive function in major depressive disorder patients were compared before and after treatment.Results ①The HAMD score was not significantly different before treatment between Chinese medicine group and Western medicine group [29.4±6.4 vs 29.6±5.5,P0.05].HAMD score was lower in Chinese medicine group than in Western medicine group after treatment [11.6±4.1 vs 13.7±4.3,P0.05].The HAMD reductive rate in Chinese medicine group was significantly higher than that in Western medicine group [（61.5 ± 6.3）% vs（53.7 ± 6.1）%,P0.05].②Compared with pre-treatment,the P500 latency was shortened,while the P500 amplitude was prolonged in two groups after treatment（P0.05）.③Before treatment,the P500 latency was significantly higher,and the P500 amplitude was significantly lower in Chinese and Western medicine groups than that in control group（P 0.05）.The P500 latency and amplitude in Chinese medicine group were not different from control group after treatment（P0.05）.The P500 latency in Western medicine group was not different from control group（P0.05）,while the P500 amplitude in Western medicine group was still significantly lower than that in control group after treatment（P0.05）.Conclusion Qishen Fukang capsule and fluoxetine can improve significantly visuo-spatial rotation cognitive function in major depressive disorder patients.Qishen Fukang capsule is superior to fluoxetine for improving the ability of visuo-spatial rotation of major depressive disorder in short term.
出处
《山西医科大学学报》
CAS
2012年第12期900-903,共4页
Journal of Shanxi Medical University
基金
军队中医药科研专项基金资助项目(10ZYX108)
关键词
芪参复康胶囊
氟西汀
重性抑郁症
视觉空间旋转
事件相关电位
Qishen Fukang capsule
fluoxetine
major depressive disorder
visuo-spatial rotation
event-related potential（ERP）
