摘要
目的 观察 8种丹参素衍生物对兔血小板聚集性的影响。方法 体外腺苷二磷酸 (ADP)诱导兔血小板聚集。结果 8种丹参素衍生物 β 苯基乳酸 (PLA)、对氟苯基乳酸 (p FPLA)、邻氟苯基乳酸 (o FPLA)、对甲基苯基乳酸 (p MPLA)、邻甲基苯基乳酸 (o MPLA)、邻氯苯基乳酸 (o CIPLA)、间氯苯基乳酸 (m CIPLA)、呋喃基乳酸 (FLA)和乙酰水杨酸 (ASA)对ADP诱导的家兔血小板聚集性均有剂量依赖的抑制作用 ,其 5 0 %聚集抑制浓度 (IC50 )值分别为 4.37、6 .14、9.32、7.5 6、2 .73、3.0 7、6 .30、7.30和 7.2 4(× 10 -3 mol·L-1)。丹参素作用较弱。结论 8种丹参素衍生物均具有体外抗血小板聚集活性。
Purpose The aim of this study was to observe the effect of eight danshensu's derivatives on rabbit platelet aggregation. Methods Addition of adenosine diphophate (ADP) to rabbit platelet rich plasma (PRP) resulted in platelet aggregation in vitro . Results The results showed that the eight danshensu's derivatives β phenyl lactic acid (PLA),p FPLA,o FPLA,p MPLA,o MPLA,o CIPLA,m CIPLA,FLA and acetylsalicylic and (ASA) inhibited significantly rabbit platelet aggregation induced by ADP in vitro, and their concentration causing a 50% inhibition (IC 50 ) of platelet aggregation were 4.37,6.14,9.32,7.56,2.73, 3.07 , 6.30 ,7.30 and 7.24 (×10 -3 mol·L -1 ),respectively.Danshensu is weaker potent agent. Conclusions The present study suggests that the eight danshensu's derivatives possess the anti aggregatory activities in vitro .
出处
《上海医科大学学报》
CSCD
2000年第3期181-182,184,共3页
Journal of Fudan University(Medical Science)
关键词
丹参素
衍生物
血小板聚集
兔
ADP
danshensu and its derivatives
β phenyl lactic acid
acetylsalicylic acid
platelet aggregation
adenosine diphosphate
