摘要
目的测定丙泊酚在剖宫产手术中单次静注后产妇静脉血和新生儿脐血中的药物浓度,观察丙泊酚对新生儿Apgar评分的影响。方法选取60例择期剖宫产的足月产妇,随机分为丙泊酚组和对照组,均采取硬膜外麻醉,丙泊酚组于切皮前单次静注1.5 mg/kg丙泊酚。于新生儿娩出、脐带结扎后分别抽取母体外周静脉血和脐静脉血,用高效液相色谱-荧光法检测法,分别测定母体外周静脉血(MV)和新生儿脐静脉血(UV)中丙泊酚的血药浓度。结果丙泊酚组在母体静脉血中药物浓度为(2.032±1.340)μg/mL,脐静脉血中药物浓度(0.701±0.583)μg/mL。两组新生儿Apgar评分无明显差异(P﹥0.05),丙泊酚组UV血药浓度远低于MV血药浓度(P<0.01),UV血药浓度与Apgar评分无相关关系(P﹥0.05)。结论丙泊酚1.5 mg/kg单次静注用于剖宫产手术对新生儿Apgar评分无明显影响。
Objective To observe the blood concentration of puerperas and fetuses in epidural anesthesia induced by propofol for cesarean section and to determine the effects on puerperas and fetuses. Methods Sixty puerperas took cesarean section under epidural anesthesia were randomLy and equally divided into two groups： propofol group （group A,n = 30） and control group（group B ,n = 30）.The puerperas in propofol group received 1.5 mg/kg propofol before skin incision.Blood samples withdrawn from MV, UV before ligature of the cord.The concentrations were measured by HPLC. Results The mean value in maternal venous blood（MV） was （2.032±1.340） μg/mL at the time of delivery. Propofol crossed the placen- tal barrier with level in the umbilical vein blood （UV） of （0.701±0.583）μg/mL. There was no significant difference in two groups in Apgar scores of newborn infants（P 〉 0.05）. Maternal concentrations were always greater than umbilical venous con- centrations at delivery（P 〈 0.01 ）.No correlation was found between the concentrations and Apgar scores （P 〉 0.05）. Con- elusion There were no obvious influence of propofol（ 1.5 mg/kg） intravenously on the Apgar scores of fetuses.
出处
《中国现代医生》
2012年第34期94-95,共2页
China Modern Doctor
