摘要
目的探讨血尿酸升高对2型糖尿病早期肾病的影响。方法根据血尿酸水平将2型糖尿病患者分成正常尿酸(NUA)组68例和高血尿酸(HUA)组52例,测定空腹血糖(FBG)、糖化血红蛋白(HbA1c)、血尿β2微球蛋白(β2-MG)、尿微量白蛋白(MAU)、尿N-乙酰-B-D-氨基葡萄糖苷酶(NAG)及尿肌酐,计算尿白蛋白尿肌酐比(ACR)及体重指数(BMI),进行统计学分析。结果 HUA组患者的尿NAG、ACR及血尿β2-MG均较NUA组升高,差异有统计学意义(P<0.05)。血尿酸水平与尿ACR、NAG及血尿β2-MG均呈正相关。结论血尿酸升高可加重2型糖尿病患者的早期肾损伤。
Objective To study the effect of serum uric acid（SUA） on early renal damage in patients with type 2 diabetes mellitus.Methods We chose 120 cases with diabetes,according to the level of SUA.The patients were classified into two groups：normal uric acid group（NUA,n=68） and high uric acid group（HUA,n=52）.Fasting blood glucose（FBG）,HbA1c,SUA,blood and urine β2 microglobulin（β2-MG）,urine microalbumin（MAU）,urine N-acetyl-beta-D-glucosaminidase（NAG） and urine creatinine were detected.The diferences between the two groups were compared.Results The levels of urine NAG,ACR,blood and urine β2-MG in HUA group were higher than those in NUA group,with statistically significant differences（P0.05）.Urine NAG,ACR,blood and urine β2-MG levels were positively correlated with SUA（P0.05）.Conclusions The high level of SUA has great significance on the injury and development of DN.Patients with type 2 diabetes mellitus are apt to develop early renal damage.
出处
《安徽医药》
CAS
2012年第12期1825-1826,共2页
Anhui Medical and Pharmaceutical Journal
