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利培酮和氯氮平、喹硫平对精神分裂症患者脂代谢影响比较 被引量:1

Risperidone and clozapine,quetiapine impact on lipid metabolism in patients with schizophrenia
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摘要 目的:探讨利培酮、氯氮平与喹硫平对精神分裂症患者血脂的影响。方法:将178例精神分裂症患者随机分为利培酮组90例,氯氮平组68例,喹硫平组20例;于治疗前及治疗第4、8周末晨间空腹采血,测定总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)。结果:治疗前后氯氮平组的CHOL差异均有统计学意义(P<0.05),TG较治疗前显著升高(P<0.01);利培酮组TG浓度差值(0.58±0.41)mmol/L,差异有统计学意义(P<0.05)。喹硫平组TG浓度差值(0.16±0.20)mmol/L,无统计学差异(P>0.05)。其他各项指标与治疗前比较差异无显著性(P>0.05)。氯氮平和利培酮对TG、CHOL的影响程度氯氮平大于利培酮。结论:利培酮与氯氮平对精神分裂症患者血脂均有影响,氯氮平对脂代谢的影响大于利培酮,喹硫平最低。 Objective:To study the influence of risperdal,clozapine and quetiapine on blood-lipid level of patients with schizophrenia.Methods: 178 cases of schizophrenia patients were randomly divided into risperdal group(90 cases),clozapine group(68 cases),quetiapine group(20 cases).Before treatment and treatment at the fourth and eighth,weekend,the levels of total cholesterol(TC),triglycerides(TG),high-density lipoprotein(HDL),low density lipoprotein(LDL),apolipoprotein A(ApoA),apolipoprotein B(ApoB) in the fasting plasma were determined.Results: CHOL level had statistical difference in clozapine group before and after treatment(P0.05),TG increased after treatment(P0.01).In risperdal group,TG had statistical difference before and after treatment with the differential concentration of(0.58±0.41) mmol/L(P0.05).In quetiapine group,TG had no statistical difference before and after treatment with the differential concentration of(0.16±0.20) mmol/L(P0.05).Other indicators had no significant difference before and after treatment(P0.05).The effect of clozapine on TG and CHOL were greater than that of risperdal.Conclusion: Risperdal and clozapine both had effect on blood-lipid of patients with schizophrenia,and clozapine had greater effect on lipid metabolism than risperdal,while quetiapine had the least effect.
出处 《中国卫生检验杂志》 北大核心 2012年第12期2878-2879,共2页 Chinese Journal of Health Laboratory Technology
关键词 氯氮平 利培酮 喹硫平 精神分裂症 脂代谢 Clozapine Risperdal Quetiapine Schizophrenia Lipid metabolism
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