摘要
目的:了解恶性肿瘤患者发生非发酵菌获得性感染临床特征及耐药性,为临床合理使用抗菌药物提供依据。方法:对312例确诊为恶性肿瘤患者在住院治疗过程中发生医院内获得性非发酵菌感染的病原菌构成及耐药性进行回顾性分析。结果:恶性肿瘤合并医院非发酵菌获得性感染主要为肺癌患者,占26.6%;312株非发酵菌以铜绿假单胞菌检出率最高,占46.5%,其次是鲍氏不动杆菌,占37.5%.药敏试验显示5种非发酵菌对多种抗生素均表现为高度耐药或多重耐药,高于相关研究,差异有统计学意义(P<0.05)。结论:恶性肿瘤患者发生非发酵菌医院内获得性感染耐药率高,治疗困难,临床应依据药敏试验结果合理使用抗菌药物,以减少耐药菌株的产生。
Objective：To understand the clinical features and drug resistance of nonfermenters in patients with malignant tumors,who had suffered hospital-acquired infection by nonfermenters,so as to provide basis for rational use of antibiotics in clinic.Methods： Three hundred and twelve malignant tumor inpatients were involved in this study,the constitution and drug resistance of pathogen,which had resulted in hospital-acquired nonferementers infection,were analyzed retrospectively.Results： Lung cancer patients were the main force of malignant tumor patients complicated by hospital-acquired nonferementers infection,accounting for 26.6%.Among the 312 nonfermenters,pseudomonas aeruginosa had the highest detection rate（46.5%）,followed by acinetobacter baumannii（37.5%）.The drug susceptibility test showed that five kinds of nonfermenters were highly resistant or multi-drug resistant to several antibiotics,higher than the results in former study,and the difference had statistical significance（P0.05）.Conclusion： Patients with malignant tumor complicated by hospital-acquired nonferementers infection were highly resistant to antibiotics,resulting in difficult treatment,so clinical rational use of antibiotics should be based on susceptibility test results,in order to reduce the emergence of drug-resistant strains.
出处
《中国卫生检验杂志》
北大核心
2012年第12期3014-3016,共3页
Chinese Journal of Health Laboratory Technology
关键词
恶性肿瘤
非发酵菌
获得性感染
耐药性
Malignant tumors
Nonfermenters
Acquired infections
Drug resistance
