摘要
目的探讨神经精神狼疮(NPSLE)患者的临床特点及早期诊断、早期治疗。方法回顾性分析65例NPSLE的临床表现、实验室检查、影像学表现、并发症、治疗和转归。结果 9例以神经精神症状首发,56例在SLE病程中各个阶段出现了各种神经精神症状;脑脊液检查,60%(40例)患者脑脊液蛋白升高;57例行头颅MRI检查者46例出现异常信号影,11例头颅MRI检查未见异常者CSF蛋白均升高;治疗后除1例并狼疮肾炎者死亡外,其余患者均有不同程度的缓解。结论脑脊液检查及头颅MRI结合临床可以协助NPSLE的早期诊断。早期诊断及早期合理治疗尤为重要。
Objective To explore the clinical characteristics, early diagnosis and early treatment of the neuropsychiatric lupus erythematosus （NPSLE） .Methods A retrospective study was used to analyze the clinical manifestations, laboratory examinations,imaging features,complications,treatment,and prognosis of 65 patients diagnosed with NPSLE.Results Neuropsychiatric symptoms were the first appearance in 9 cases.56 patients with SLE appeared with various neuropsychiatric symptoms in one phase of the disesase. 60% （40 cases） had a raise of protein in cerebrospinal fluid. 46 in 57 cases appeared with abnormal signals in the cerebral MRI. 11 cases without abnomalities in the cerebral MRI had raised protein in cerebrospinal fluid. After treatment, all patients had some degree of relief except a patient with lupus nephritis died.Conclusion The combination of clinical manifestation , cerebrospinal fluid examination and cerebral MRI helps early diagnosis of NPSLE. Early diagnosis and rational treatment is important.
出处
《云南医药》
CAS
2012年第6期521-523,共3页
Medicine and Pharmacy of Yunnan
关键词
系统性红斑狼疮
神经精神性狼疮
Systemic lupus erythematosus
Neuropsychiatric lupus
