期刊文献+

从繁殖力制约法则看现有肿瘤生长理论的不合理性 被引量:9

The Fecundity Restriction Dogma and Irrationality of Current Cancer Theory
下载PDF
导出
摘要 繁殖力受三个方面的因素制约,即寿命、形体和食物链的位置。寿命越长,繁殖力越弱;形体越大,繁殖力越弱;在食物链的位置越高,繁殖力越弱。繁殖力制约法则是维持生物界物种平衡和多样性的基本法则。现在的肿瘤生长理论中,肿瘤细胞一方面"抗凋亡",另一方面却不断增殖,显然与这一法则相矛盾。 The fecundity is restricted by three 3 factors, including lifespan, body size, and the position in food chain. The longer the lifespan, the weaker the fecundity; the bigger the body size, the weaker the fecundity; the higher in food chain, the weaker the fecundity. This dogma plays a key role in maintaining the balance and diversity of species. While the current cancer theory states that cancer cells are both "resistant to apoptosis", and proliferate limitlessly. Obviously it contra dicts this dogma, and thus is potentially wrong in this point.
作者 王瑞安
出处 《医学与哲学(B)》 2012年第12期44-46,共3页 Medicine & Philosophy(B)
基金 国家自然科学基金资助项目 项目编号:30870923 30971535 国家973项目 项目编号:2009CB521701
关键词 寿命 繁殖力 法则 肿瘤 理论 lifespan, fecundity, dogma, tumor, theory
  • 相关文献

参考文献19

  • 1Begley C G, Ellis L M. Drug development: Raise standards for preclinical cancer research[J]. Nature, 2012,483 ( 7391) : 531 - 533.
  • 2Zhan Z, Ding Y, Zhao R, et al. Rapid functional divergence of a newly evolved polyubiquitin gene in Drosophila and its role in the trade-off between male fecundity and lifespan[J]. Mol Biol Evol, 2012,29(5):1407 1416.
  • 3O'Reilly L A, Huang D C, Strasser A. The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry[J]. EMBO J,1996,15(24) :6979-6990.
  • 4Broughton S J, Piper M D, Ikeya T, et al. Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands[J]. Proe Natl Acad Sci U S A, 2005,102(8) : 3105 - 3110.
  • 5Hanahan D, Weinberg R A. The hallmarks of cancer[J]. Cell, 2000,100(1) :57-70.
  • 6朱亚勤,赵梅芬.加速凋亡引入肿瘤的进程[J].医学与哲学,1999,20(8):21-22. 被引量:2
  • 7张文红,药立波,刘新平,李福洋.生存,还是死亡——从细胞凋亡看矛盾的对立统一[J].医学与哲学,2003,24(2):43-44. 被引量:1
  • 8Baserga R. The relationship of the cell cycle to tumor growth and control of cell division: a review[J]. Cancer Res, 1965,25,581 595.
  • 9王瑞安.肿瘤细胞的周期没有短[J].中华病理学杂志,2012,41(11):789-791. 被引量:8
  • 10王瑞安,李擒龙,王敬博,覃君慧,李增山,闫庆国.肿瘤细胞周期的长与短及凋亡的多与少——肿瘤生长的定律[J].医学争鸣,2012,3(3):30-31. 被引量:17

二级参考文献15

  • 1文国艺,卢克焕.两种方法对牛体外受精及体外发育的影响[J].中国兽医学报,1996,16(5):510-513. 被引量:14
  • 2朱学军,于益芝,曹雪涛.肿瘤的“自杀基因”疗法研究进展[J].国外医学(肿瘤学分册),1996,23(1):36-39. 被引量:9
  • 3陈大元.受精生物学[M].北京:科学出版社出版,2000.419.
  • 4郭继彤 李裕强 等.从屠宰山羊卵巢制备核移植受体卵母细胞的研究[J].西北农业学报,1998,7(5):127-130.
  • 5Begley CG, Ellis LM. Drug development : raise standards forpreclinical cancer research. Nature, 2012,483(7391) :531-533.
  • 6Massagu6 J. G1 cell-cycle control and cancer. Nature, 2004, 432(7015) : 298-306.
  • 7Carrel A. Mechanism of the formation and growth of malignanttumors. Ann Surg, 1925 , 82(1):1-13.
  • 8Cowdry EV. Cancer cells. Philadelphia: WB Saunders Company,1955; 146.
  • 9Becker FF. Cancer: a comprehensive treatise. Biology of tumors:cellular biology and growth. New York : Plenum Press, 1975 :201-214.
  • 10Baserga R. The relationship of the cell cycle to tumor growth andcontrol of cell division: a review. Cancer Res, 1965 , 25 :581-595.

共引文献18

同被引文献113

  • 1Soto AM,Sonnenschein C. The tissue organization field theory of cancer: a testable replacement for the somatic mutation the- ory[J]. Bioessays,2011,33(5) :332-40.
  • 2Karp RD, Johnson KH, Buoen LC, et al. Tumorigenesis by Mil lipore filters in mice: histology and ultrastructure of tissue re actions as related to pore size[J]. J Natl Cancer Inst, 1973,51 (4) : 1275-85.
  • 3Baker SG, Kramer BS. Paradoxes in carcinogenesis: new op portunities for research directions [J]. BMC Cancer, 2007, 7:151.
  • 4Hanahan D,Weinberg RA. The hallmarks of eancer[J]. Cell, 2000,100 ( 1 ) : 57-70.
  • 5Lipponen PK,Aaltomaa S. Apoptosis in bladder cancer as re- lated to standard prognostic factors and prognosis [J]. J Pathol, 1994,173(4) :333-9.
  • 6Lipponen P, Aaltomaa S, Kosma VM, et al. Apoptosis in breast cancer as related to histopathological characteristics and prog- nosis[J]. Eur J Cancer, 1994,30A(14) :2068-73.
  • 7Lipponen P. Apoptosis in breast cancer: relationship with oth- er pathological parameters [J].Endocr Relat Cancer, 1999, 6 (1):13-6.
  • 8Nishimura R, Nagao K, Miyayama H,et al. Apoptosis in breast cancer and its relationship to clinicopathological characteristics and prognosis[J]. J Surg Oncol, 1999,71 (4) : 226-34.
  • 9Carrel A. Mechanism of formation and growth of malignant tumors[J].Ann Surg, 1925,82( 1 ) :1-13.
  • 10Wang RA, LiQ L, Li ZS, et al. Apoptosis drives cancer cells proliferate and metastasize[J].J Cell Mol Med, 2013, 17 ( 1 ) : 205-11.

引证文献9

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部