摘要
1目的 探讨进行期重症寻常型银屑病病人外周血 T淋巴细胞免疫功能的变化及影响因素。2方法采用免疫酶技术和淋巴细胞培养法 ,对 49例病人和 2 0例正常人的外周血 T淋巴细胞及其亚群和膜白细胞介素 - 2受体 (m IL - 2 Rα)进行检测。 3结果 未服用抗癌药的初发和长病程病人血中 CD3,CD4细胞百分率、CD4/CD8比值和 m IL - 2 Rα的表达率均明显低于正常人 (F =3.35～ 11.88,q=2 .83～ 4.2 8,P<0 .0 5 ,0 .0 1) ;曾长期服用抗癌药的长病程病人 ,CD8细胞百分率也明显低于正常人 (F=4.2 2 ,q=5 .78,P<0 .0 1) ;未服用抗癌药的长病程病人 ,CD3,CD4细胞百分率和 m IL - 2 Rα的表达率均明显低于初发者 (q=2 .83～ 3.76 ,P<0 .0 5 ,0 .0 1) ;长病程病人中 ,曾长期服用抗癌药者血中 CD3,CD4,CD8细胞百分率和 m IL- 2 Rα的表达率均明显低于未服用抗癌药者 (q=2 .86～ 3.76 ,P<0 .0 5 ,0 .0 1)。 4结论 银屑病病人 T淋巴细胞免疫功能显著低下 ;病程延长和服用抗癌药是促使病人
Objective\ To study the change and the influence factors of the immune function of T lymphocytes in the peripheral blood of patients with severe psoriasis vulgaris at the active stage.\ Methods\ Immunoenzymatic technique and lymphocyte culture were utilized to determine T lymphocytes, T lymphocyte subpopulations and cell membrane interleukin 2 receptor (mIL 2Rα), in 49 patients and 20 normal persons.\ Results\ The percentage of CD 3 and CD 4 cells, the ratio of CD 4/CD 8 and the expression rate of mIL 2Rα in the blood of the incipient and long course patients without taking anticarcinogen were significantly lower than those of the normal persons ( F=3.35-11.88,q=2.83-4.28,P <0.05,0.01), while the percentage of CD 3 and CD 4 and the expression rate of mIL 2Rα in the blood of the long course patients without taking anticarcinogen were distinctly lower than those of the incipient patients ( q=2.83-3.76,P <0.05,0.01). The percentage of CD 8 cells in the blood of the long course patients taking anticarcinogen for a long term was obviously lower than that of the normal persons ( F=4.22,q=5.78,P <0.01). In long course patients, the percentage of CD 3,CD 4 and CD 8 cells and the expression rate of mIL 2Rα in the blood of the patients taking anticarcinogen for a long term were significantly lower than those of the patients without taking anticarcinogen ( q=2.86-3.76,P <0.05,0.01).\ Conclusion\ The immune function of T lymphocytes of patients with psoriasis is distinctly low. The prolongation of the course and taking anticarcinogen are important influence factors, which will prompt the immune function of T lymphocytes of patients further low.\;[
出处
《齐鲁医学杂志》
2000年第1期4-6,共3页
Medical Journal of Qilu
