摘要
本文以给动物灌服寒凉药及结扎冠状动脉并逐渐缩窄升主动脉口径制作家兔充血性心力衰竭少阴病阳虚水停证模型,旨在探讨加味真武汤对其心肌细胞凋亡的影响。结果表明,造模动物出现症状,各脏器改变及血液流变学改变,证明CHF少阴病阳虚水停证模型成功。加味真武汤可明显抑制模型家兔心肌细胞凋亡,与空白组相比有显著性差异(p<O.01),其作用与西药对照组相当。提示加味真武汤对CHF心肌细胞凋亡的抑制作用,可能是其发挥治疗作用的机理之一。
To investigate the effect of modified Zhenwu decoction on cardiac muscle cell apoptosis in rabbit. The model of congestive heart failure, Shaoyin disease auumulation of water due to Yang deficiency syndrome was established by filling the rabbit with the cold prescription, tying up the coronary artery and narrowing gradually the calibre of the ascending aorta. The results showed the animal model had symptoms and there were changes in every organ and hemorrheology, which proved the animal model was successful. The modified Zhenwu decoction could obviously inhibit the cardiac muscle cell apoptosis in rabbit model. There were significant differences between the control group and the treatment group (P < 0.01). The effect was correspondent with that of the control group with western medicine. It indicated that the modified Zhenwu decoction has direct sup-pressive effects in cardiac muscle cell apoptosis, which might be one of its treating machanisms.
出处
《中国医药学报》
CSCD
2000年第2期26-29,38,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
