摘要
目的考察复方穿蛭透皮贴剂对实验动物皮肤的急性毒性、刺激性及过敏性。方法复方穿蛭透皮贴剂对健康家兔进行皮肤急性毒性试验、皮肤刺激性试验及对健康豚鼠皮肤过敏性试验。结果复方穿蛭透皮贴剂对破损皮肤组试药中、高剂量组表现为轻度刺激性,其余各组均无急性毒性和刺激性。对豚鼠完整皮肤无致敏作用。结论本实验所用复方穿蛭透皮贴剂经皮肤给药安全。
Objective To investigate acute dermal toxicity,irritating,allergic of compound chuanzhi transdermal system through the skin.Methods To carry out acute skin toxicity and skin irritation test in healthy rabbits and dermal allergic test in healthy guinea pigs using compound chuanzhi transdermal system.Results The medium and high dose group showed slight stimulation broken skin of rabbits,the other groups had no acute toxicity and no irritation on integrated and broken skin of rabbits,and it had no hypersensitivity on integrated skin of guinea pigs.Conclusions The experiment indicated that it was safe to administrate the compound chuanzhi transdermal system through the skin.
出处
《中国地方病防治》
2012年第6期422-424,共3页
Chinese Journal of Control of Endemic Diseases
基金
吉林省教育厅重点资助项目(吉教科合字[2011]第283号)
关键词
复方穿蛭透皮贴
急性毒性
刺激性
过敏性
Compound chuanzhi transdermal system
Acute dermal toxicity
Irritation
Allergic
