期刊文献+

妊娠滋养细胞肿瘤nm23H_1和PCNA的表达及其临床意义 被引量:2

Exprssion of nm23H_1 and PCNA in gestational trophoblastic tumors and its clinical significance
下载PDF
导出
摘要 目的 观察 nm2 3H1 表达与妊娠滋养细胞肿瘤转移及细胞增殖状态的关系 ,并观察化疗对滋养细胞肿瘤细胞增殖状态的影响。方法 采用免疫组化方法检测 48例妊娠滋养细胞肿瘤手术标本、10例完全性葡萄胎和10例正常早孕绒毛组织刮宫标本中 nm2 3H1 和 PCNA的表达。结果 正常早孕绒毛或葡萄胎的 nm2 3H1 表达较妊娠滋养细胞肿瘤强 (P<0 .0 1) ,妊娠滋养细胞肿瘤中侵蚀性葡萄胎较绒癌强 (P<0 .0 5 ) ,WHO分期 、 期者较 、 期者强 (P<0 .0 5 ) ,WHO评分非高危组较高危组强 (P<0 .0 5 )。妊娠滋养细胞肿瘤 PCNA阳性细胞数高于正常早孕绒毛 (P<0 .0 5 )。结论  nm2 3H1 免疫组化检测对妊娠滋养细胞肿瘤转移和预后的评估以及化疗方案的选择具有参考价值。 Objective To evaluate the relationship between nm23H 1 expression levels and metastasis and proliferation of gestational trophoblastic tumors(GTTs) and to observe the influence of chemotherapy on proliferative status of GTTs.Methods Expression of nm23H 1 and PCNA was determined in 48 cases of gestational trophoblastic tumors,10 complete hydatidiform mole and 10 normal first trimester trophoblast with immunohistochemical methods.Results The results show that nm23H 1 expression was stronger in first trimeter trophoblasts and hydatidiform mole than that in GTTs( P <0.01).nm23H 1 expression in invasive hydatidiform mole was stronger than that in choriocarcinoma( P <0.05);it in those of WHO stage I,II was stronger than that in stage Ⅲ,Ⅳ;and WHO scoring non high risk group had stronger nm23H 1 expression than high risk group.GTTs have more PCNA positive trophoblastic cells than normal first trimester trophoblast( P <0.05).Conclusion nm23H 1 detection has referential value in evaluating metastasis potential and prognosis of GTTs.
出处 《实用肿瘤杂志》 CAS 北大核心 2000年第2期99-101,共3页 Journal of Practical Oncology
关键词 滋养细胞肿瘤 葡萄胎 NM23H1基因 PCNA trophoblastic neoplasms/drug therapy hydatidiform mole immunohistochemistry oncogenes
  • 相关文献

参考文献2

  • 1Qian M,Clin Med J Engl,1997年,110卷,2期,142页
  • 2Cheung A N,Histopathology,1993年,22卷,6期,565页

同被引文献31

  • 1乔宠,程大丽,张淑兰,王春晖,林其德.KiSS-1基因和基质金属蛋白酶-9在滋养细胞浸润调控中的作用[J].中华医学杂志,2005,85(12):839-842. 被引量:16
  • 2石一复.仍应重视妊娠滋养细胞疾病/肿瘤的研究[J].中华肿瘤防治杂志,2006,13(15):1121-1124. 被引量:4
  • 3曹泽毅.中华妇产科学(第1版)[M].北京:人民卫生出版社,2000.795.
  • 4Yang X,Zhang Z,Jia C et al.The relationship between expression of c -ras,c -crbB -2,nm23,and p53 gene products and development of trophoblastic tumor and their predictive significance for the malignant transformation of complete hydatidiform mole.Gynecol Oncol,2002,85 (3):438~444
  • 5Cheung AN,Srivastava G,Chung LP et al.Expression of the p53 gene in trophoblastic cells in hydatidiform moles and normal human placentas.J Reprod Med,1994,39 (3):223~227
  • 6Shi YF,Xie X,Zhao CL et al.Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours.Br J Cancer,1996,73(10):1216~1219
  • 7Fulop V,Mok SC,Genest DR et al.p53,p21,Rb and mdm2 oncoproteins.Expression in normal placenta,partial and complete mole,and choriocarcinoma.J Reprod Med,1998,43 (2):119 ~127
  • 8Cheung AN,Shen DH,Khoo US et al.Immunohistochemical and mutational analysis of p53 tumor suppressor gene in gestational trophoblastic disease:correlation with mdm2,proliferation index,and clinicopathologic parameters.Int J Gynecol Cancer,1999,9 (2):123 ~130
  • 9Fulop V,Mok SC,Genest DR et al.c-myc,c-erbB-2,c-fms and bcl-2 oncoproteins.Expression in normal placenta,partial and complete mole,and choriocarcinoma.J Reprod Med,1998,43 (2):101 ~110
  • 10Wong SY,Ngan HY,Chan CC et al.Apoptosis in gestational trophoblastic disease is correlated with clinical outcome and Bcl-2 expression but not Bax expression.Mod Pathol,1999,12 (11):1025 ~1033

引证文献2

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部