摘要
瞬时受体电位阳离子通道6(TRPC6)在肾、心脏和肺等多个器官均有表达,是构成细胞膜钙库操纵性通道的分子基础,在细胞信号转导中起着重要作用。其基因突变或过量表达可引起细胞内钙离子信号通路异常,使得大量钙离子内流,导致机体各种病理生理过程的变化。通过特异性TRPC6通道抑制剂和RNA干扰技术干预其在相关疾病中的过量表达,可以改善或缓解病情,提示TRPC6可能作为疾病治疗的新靶点。本文就近年来关于TRPC6作为疾病治疗靶点的研究进展进行综述。
Transient receptor potential channel 6（TRPC6） expresses in several organs,such as kidney,heart and lung.It serves as molecular basis of calcium store operated channels in cell membranes and plays an important role in cell signal transduction. The gene mutation or over-expression of TRPC6 may lead to abnormality of calcium signaling pathway intracellular with a great quantity of Ca 2 ＋ influx,which results in the changes of various pathophysiologic process.People intervene its over-expression with specific TRPC6 inhibitor and RNA interference in relevant diseases to improve and relieve patients＇ condition,therefore TRPC6 may be a new target for disease therapy.This article reviews research progress of TRPC6 acting as disease treatment target.
出处
《国际药学研究杂志》
CAS
2012年第6期474-477,共4页
Journal of International Pharmaceutical Research
基金
广东省中山市科技计划资助项目(20102A021)
