摘要
目的麻醉诱导前吸入硫酸沙丁胺醇气雾剂(万托林),观察其对腹腔镜手术呼吸力学的影响。方法合并慢性肺阻塞疾患(COPD)的拟行腹腔镜手术的患者40例,随机分成观察组和对照组各20例,观察组:患者给予万托林200μg(2揿)后面罩吸氧;对照组:单纯面罩吸氧,30min后开始麻醉诱导。记录监测时点的气道峰压、气道平台压、气道阻力、胸肺顺应性的变化。结果两组患者气腹后的气道峰压、气道平台压、气道阻力高于插管后5min,胸肺顺应性低于插管后5min,P<0.05;插管后5min、气腹后5min以及30min的气道峰压、气道平台压、气道阻力观察组低于对照组,胸肺顺应性观察组高于对照组,P<0.05。结论硫酸沙丁胺醇气雾剂能降低COPD患者腹腔镜手术的气道压力和气道阻力,增加胸肺顺应性,有利于术中呼吸管理,提高了麻醉的安全性。
[Objective] To study the effects of salbutamol aerosol inhalation prior to anesthesia induction on pneodynamic during laparoscopic operation in patients with chronic obstructive pulmonary disease.[Methods] 40 patients with concomitant COPD,scheduled for laparoscopic operation were randomly allocated into observation group（n=20） and control group（n=20）.Salbutamol aerosol 200μg（two puffs） was administered according to instructions before oxygenation via mask in observation group,whereas in control group no aerosol was given before oxygenation via mask.Anesthesia induction was initiated after 30 minutes oxygenation in both groups.Change of peak and platform pressure of airway,airway resistance and chest-lung compliance were monitored.[Results] The peak of and platform pressure of airway,airway resistance after pneumopertioneum were higher than 5 minutes after intubation in two groups of patients.Chest-lung compliance was lower 5 minutes after intubation,P 0.05 or P 0.01;When compared to control group,the peak of and platform pressure of airway,airway resistance in 5 minters after intubation and 5 minutes and 30 minutes after pneumopertioneum were lower in observation group and chest-lung compliance was higher in observation group,P 0.05.[Conclusions] Salbutamol aerosol inhalation can reduce airway pressure and airway resistance and increase chest-lung compliance during laparoscopic operation in patients with COPD.To advantage breathing management during operation,improve safety anesthesia.
出处
《中国内镜杂志》
CSCD
北大核心
2012年第10期1046-1049,共4页
China Journal of Endoscopy
关键词
沙丁胺醇
肺疾病
慢性阻塞性
腹腔镜手术
呼吸动力学
salbutamol
pulmonary disease
chronic obstructive
laparoscopic operation
pneodynamic
