摘要
目的比较腹腔镜与开腹手术治疗胃癌的临床疗效。方法回顾性分析2007年1月—2010年12月收治的胃癌患者103例,分为两组,其中采用腹腔镜胃癌根治术(LAP组)治疗49例,采用传统开腹胃癌根治术(OPEN组)治疗54例,比较两组的手术时间、手术切口长度、术中出血量、术后胃肠道恢复时间、清扫淋巴结数、术后住院天数、术后并发症等。结果 LAP组的术中出血量、胃肠道恢复时间和住院天数都明显少于OPEN组,无瘤生存率也均优于OPEN组,但其手术时间较长,两组存在统计学差异(P<0.05);此外LAP组局部复发、远处转移和并发症发生率与OPEN组无统计学差异(P>0.05)。术后1周LAP组外周血T淋巴细胞亚群CD3+、CD4+、CD4+/CD8+及NK细胞活性均高于OPEN组(P<0.05)。结论腹腔镜胃癌根治术治疗胃癌安全可靠,具有创伤小、出血少、术后恢复快等优点。
Objective To compare the therapeutic effects between laparoscopic gastrectomy and open gastrectomy for gastric cancer. Methods A retrospective analysis of 103 patients with gastric cancer from January 2007 to December 2010,which were divided into LAP group(including 49 patients received laparoscopic gastrectomy) and OPEN group(including 54 patients received conventional laparotomy).The operative time,the length of the incision,intraoperative blood loss,postoperative gastrointestinal recovery time,postoperative hospital stay,and postoperative complications were observed and compared between the two groups. Results The intraoperative blood loss,postoperative gastrointestinal recovery time,and postoperative hospital stay were shorter,and the disease-free survival rate were higher in LAP group than those of OPEN group,but the operative time of LAP group was longer than that of OPEN group,there was statistic difference between two groups(P0.05).In addition,there was no significant difference in local recurrence,distant metastasis and complication rate between the two groups(P0.05).After a week,cell activity of T lymphocyte subsets CD3+,CD4+,CD4+/CD8+ and NK cells of the LAP group were better than the OPEN group(P0.05). Conclusion The laparoscopic gastrectomy is safe and reliable in the treatment of gastric cancer with less trauma,less bleeding and quick postoperative recover.
出处
《临床军医杂志》
CAS
2012年第6期1296-1298,共3页
Clinical Journal of Medical Officers
基金
江苏省卫生厅课题(201043231)
关键词
胃肿瘤
腹腔镜
传统开腹手术
gastric neoplasm
laparoscope
conventional laparotomy