摘要
目的 了解人白细胞抗原 (HLA) DRB1等位基因与泡球蚴病相关性 ,阐明泡球蚴病的免疫学发病机制 ,探寻泡球蚴病的易感基因或抗病基因提供线索。方法 应用PCR/SSP技术 ,对中国西部甘肃省漳县、岷县泡球蚴病高流行区 4个乡的 35例患者和 10 4例正常人群进行了HLA DRB1基因型分析。结果 患者组HLA DRB1 0 40x基因频率为 2 6 % (18/70 ) ,正常对照组为 10 % (2 0 /2 0 8)(RR =4.45 ,χ2 =13.6 7,P <0 .0 1,EF =0 .2 0 )。HLA DRB1 0 70 1基因频率 ,患者组为 3% (2 /70 ) ,正常组为 14% (2 9/2 0 8) ,(RR =0 .16 ,χ2 =6 .2 6 ,P <0 .0 5 ,PF =0 .30 )。其他等位基因频率在患者组与正常组间差异无显著意义 (χ2 =0 .0 3～ 1.87,P >0 .0 5 )。结论 HLA DRB1 0 40x基因与泡状棘球蚴病具有相关性 ,所调查地区泡球蚴病的高流行与遗传因素有关。HLA DRB1 0 70
Objective To investigat the association of HLA DRB1 alleles and the susceptibility to alveolar echinococcosis (AE). Methods Thirty five patients with AE in the high prevalence areas in the west of China were investigated for HLA DRB1 gene by PCR/SSP technique. The results were compared with 104 normal healthy peoples. Results Frequency of HLA DRB1*040x was 26% in patient group, which was significantly higher than in control group (9.62%), with a relative risk ( RR ) of 4.45 (χ 2=13.67, P <0.01), and with an etiological fraction of 0.20. Frequency of HLA DRB1*0701 allele was decreased in patient group (patient 2.86%, control 13.94%; χ 2=6.67, P <0.05), with preventable fraction of 0.30. While the frequencies of other DRB1 alleles were not significantly different. Conclusion Susceptibility to AE is strongly associated with the HLA DRB1*040x allele. The high prevalence of human AE in this region was associated with genetic factor. HLA DRB1*0701 geners resistant to Echinococcus multilocularis metacestode infection.
出处
《中华医学杂志》
CSCD
北大核心
2000年第6期414-416,共3页
National Medical Journal of China
