摘要
目的观察比较盐酸氨基葡萄糖单独使用及与硫酸软骨素联合使用治疗腰椎小关节骨关节炎(LFOA)的临床疗效。方法 2009年1月-2011年1月,将80例LFOA患者随机分成两组,A组口服盐酸氨基葡萄糖,B组口服盐酸氨基葡萄糖和硫酸软骨素两种药物,6周为1个疗程,间断治疗4个疗程。分别比较用药前与用药后3、6周及5、8、11个月时的日本骨科协会(JOA)评分、晨僵和压痛程度变化。结果治疗后,两组的JOA评分在各观察时点均增加,与治疗前比较差异有统计学意义(P<0.05)。组间行JOA评分治疗改善率的比较,在各观察时点差异均有统计学意义(P<0.05),B组JOA评分改善率优于A组。治疗3周后,两组晨僵和压痛评分均降低,与本组治疗前比较差异有统计学意义(P<0.05);组间比较,差异亦有统计学意义(P<0.05),B组晨僵和压痛程度均低于A组。第6周,第5、8、11个月,两组组间比较晨僵和压痛程度差异均无统计学意义(P>0.05),但各疗程结束后两组晨僵和压痛程度均呈持续降低趋势。结论单独应用盐酸氨基葡萄糖及盐酸氨基葡萄糖与硫酸软骨素的联合应用治疗LFOA疗效确切,联合用药优于单独应用盐酸氨基葡萄糖。
Objective To observe the clinical effect of glucosamine hydrochloride or glucosamine hydrochloride and chondroitin sulfate in combination on the treatment of lumbar facet joint osteoarthritis（LFOA）.Methods From January 2009 to January 2011,80 patients with LFOA were randomly divided into 2 groups： group A with medication of glucosamine hydrochloride and group B with medication of glucosamine hydrochloride and chondroitin sulfate in combination.Each group was treated for 4 courses and 6 weeks for every course.The clinical effect from the change of score of the items observed at each point of each group was compared with its＇ pretreatment,and the clinical effect was compared in the two groups at the same point.Results The scores of Japanese Orthopaedic Association（JOA） of the two groups increased at each observed time point.The change showed statistically significant differences compared with that of its＇ pretreatment（P0.05）.The rate of the change showed statistically significant differences compared in the two groups at each observed time（P0.05）.The scores of morning stiffness and pressure pain reduced and showed statistically significant differences in each group and in the two groups after the treatment for 3 weeks.The scores in group B reduced more than that in group A.There showed no statistically significant differences compared in the two groups in the following observed time points（P0.05）.But the scores of morning stiffness and pressure pain kept reducing.Conclusions Glucosamine hydrochloride,or glucosamine hydrochloride and chondroitin sulfate in combination have good clinical effect on LFOA.The two drugs in combination are better than glucosamine hydrochloride.
出处
《华西医学》
CAS
2012年第12期1809-1813,共5页
West China Medical Journal
关键词
盐酸氨基葡萄糖
硫酸软骨素
骨关节炎
腰椎小关节
Glucosamine hydrochloride
Chondroitin sulfate
Osteoarthritis
lumbar facet joint
