摘要
目的评价蓝芩口服液对慢性咽炎患者IL-2、TNF-α、免疫细胞亚群及临床症状的改善作用。方法选择118例慢性咽炎患者,按照随机对照原则分为2组,每组59例。研究组给予蓝芩口服液口服,每次20 mL,每日3次;对照组给予西地碘含片口含,每次1片,每日3～5次。2组均以7 d为1个疗程,连续服用2～3个疗程。观察2组患者炎症因子、免疫细胞亚群及临床症状的改善情况,并评价不良反应。结果 2组治疗后IL-2、TNF-α水平及免疫细胞亚群均较治疗前明显改善,且研究组改善程度大于对照组;研究组各主要症状的总有效率均高于对照组,其中对于咽痛、咳嗽、咽痒、咽部红肿的改善具有显著优势;2组患者治疗及随访期间均未发现明显的与药物相关的不良反应。结论蓝芩口服液可有效缓解慢性咽炎患者的临床症状及体征,且无明显毒副作用,适合在临床上推广使用。
Objective It is to evaluate the improvement of Lanqin oral liquid on IL-2,TNF-α,immune cell subsets and clinical syndromes in patients with chronic pharyngitis.Methods 118 cases of patients with chronic pharyngitis were chosen and divided into 2 group by randomized-control standard,59 cases in each group.Study group was given Lanqin oral liquid by oral administration,20mL per time and 3 times per day.Control group was given Cydiodine buccal tablets,one tablet per time and 3-5 times per day.Both the treatment courses were 7 day and they were treated for 2-3 treatment courses.The improvements of inflammatory factors,immune cell subsets and clinical syndromes of the patients in both groups were observed and the side effects were evaluated.Results The levels of IL-2 and TNF-α and immune cell subsets in both group were obviously improved,and the improvements in study group were better than that in control group.The total effective rates of every main syndrome in study group were all higher than that in control group,significant advantages for improving sore throat,cough,throat itching and red and swollen throat were found in study group.No obvious side effect related with the drugs was found in both groups during treatment and following up stage.Conclusion Lanqin oral liquid can effectively relieve the clinical symptoms and signs in patients with chronic pharyngitis without obvious side effects,it is worth wide application in clinic.
出处
《现代中西医结合杂志》
CAS
2013年第2期125-127,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
蓝芩口服液
慢性咽炎
炎症因子
免疫细胞亚群
Lanqin oral liquid
chronic pharyngitis
inflammatory factor
immune cell subset
