摘要
使用羧甲基壳聚糖(CMCS)和明胶(Gel)作为粘结剂,以沉淀法制得的纳米羟基磷灰石(HA)浆料为原料,采用溶胶-凝胶法制备出了粒径分布均匀,几何形态良好的致密HA球粒.其孔隙率为4.7%±0.6%,单粒抗压强度为(8.9±0.4)MPa(颗粒直径为0.5 mm),高于孔隙率为16.4%±0.5%的多孔球的抗压强度(7.9±0.2)MPa。仿生矿化和细胞培养的结果显示致密HA球粒具有良好的生物学性能。
By using carboxy methyl chitosan （CMCS） and gelatin （Gel） as adhesive, the nano-HA slurry which was fabricated via a precipitation process as the raw material, dense HA spheres with a uniform size distribution and good geometry were prepared successfully by means of Sol-Gel method. Dense HA spheres with a porosity of 4.7%±0.6% have a higher compressive strength （8.9 ±0.4） MPa than that of porous HA spheres （7.9± 0.2） MPa with a porosity of 16.4%±0.5% （particles with diameter of 0.5 mm）. The results of biomimetic mineralization and cell culture show that dense HA spheres have an excellent biological property.
出处
《无机材料学报》
SCIE
EI
CAS
CSCD
北大核心
2013年第1期40-44,共5页
Journal of Inorganic Materials
基金
国家重大科学研究计划(2012CB933602)
国家自然科学基金(51172188)
四川省科技支撑计划(2010FZ0048)~~
