摘要
目的测定不同病理类型肺癌患者化疗前后癌胚抗原(CEA)、糖类抗原(CA-125)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)的水平及变化。方法选择56例肺癌患者,其中腺癌24例、鳞癌17例、小细胞未分化癌15例。用电化学发光法测定化疗前后血清CEA、CA-125、CYFRA21-1、NSE的水平,再分别作对比分析。结果 CEA在肺腺癌中水平高于其他类型(P<0.05),CA-125在肺腺癌和小细胞肺癌中有较高表达(P<0.05),CYFRA21-1在肺鳞癌中水平高于其他类型(P<0.05),NSE在小细胞肺癌中水平高于其他类型(P<0.05)。显效组患者治疗前后对应肿瘤标志物水平均明显下降(P<0.01)。结论不同病理类型肺癌患者各肿瘤标志物在血清中表达水平不同,治疗显效组其水平呈不同程度下降,提示各肿瘤标志物的联合测定有助于相应肺癌的病理分型判断。
Objective Determination of different pathological types of lung cancer patients before and after chemotherapy and carcinoembryonic antigen（CEA）,carbohydrate antigen（CA-125）,cytokeratin 19 fragment（CYFRA21-1）,neuron specific enolase（NSE） levels and changes.Methods 56 cases of patients with lung cancer,including 24 cases of adenocarcinoma,17 cases were squamous cell carcinoma,small cell undifferentiated carcinoma in 15 cases.Using chemiluminescence method for the determination of serum CEA before and after chemotherapy,CA-125,CYFRA21-1,NSE levels,then make comparative analysis.Results CEA in adenocarcinoma of lung levels than the other types（P0.05）,CA-125 in lung adenocarcinoma and small cell lung cancer（P0.05）,with higher expression of CYFRA21-1 in squamous cell carcinoma of the lung levels than the other types（P0.05）,NSE in small cell lung cancer levels than the other types（P0.05）.Effective group of patients before and after treatment with corresponding tumor markers level decreased significantly（P0.01）.Conclusion Different pathological types of lung cancer patients with various tumor markers in serum levels of expression of different treatment groups,was its level was decreased in different degree,prompting the tumor marker combined determination contributes to the corresponding pathological types of lung cancer judgment.
出处
《青海医学院学报》
CAS
2012年第4期257-259,共3页
Journal of Qinghai Medical College
关键词
肺癌
病理类型
肿瘤标志物
Lung cancer Pathological types Tumor markers
