摘要
目的比较艾迪注射液联合化疗与单纯化疗对食管癌患者的疗效、毒副反应及免疫功能的影响。方法将61例食管癌患者随机分为两组。观察组在化疗开始起同时应用艾迪注射液,每次100 mL加入0.9%生理盐水500 mL静脉滴注,每天1次,连用10 d。对照组为单纯化疗。化疗方案均为DF方案(顺铂与5-氟尿嘧啶的联合用药)。结果观察组有效率36.7%,对照组为22.6%,无显著性差异(P>0.05)。观察组白细胞下降率明显低于对照组,差异有显著性(P<0.05)。观察组治疗前后免疫功能变化无显著性差异(P>0.05)。对照组患者免疫功能化疗后显著低于化疗前(P<0.05)。结论艾迪注射液联合化疗治疗食管癌,可降低化疗对患者免疫功能的影响及毒副反应,改善NKT细胞活性。
AIM To investigate the therapeutic effects, adverse reaction of Aidi Injection combined with chemotherapy and effect on immunity in contrast to chemotherapy alone. METHODS Sixty-one cases of esopha- geal carcinoma patients were randomly divided into two groups, observation group and control group. In the obser- vation group, combination of diamminedichloroplatinum and 5-fluorouracil （DF） chemotherapy plus Aidi Injection （ 100 mL） were given intravenously by dissolving in 500 mL of normal saline per day for 10 days, while only DF chemotherapy was given in the control group. RESULTS The effective rates in the observation group and the control group were 36.7% and 22. 6% , respectively, and had no significantly difference （P 〉 0.05）. Moreover, the decrease rate of white blood cell in the observation group was lower than that in the control group （P 〈 0.05 ）. The cellular immune function of patients had no significant difference when being added with Aidi Injection in the observation group （P 〉 0.05 ）. The immune function of patients in the control group decressed significantly after chemotherapy （P 〈 0. 05）. CONCLUSION Combination of DF chemotherapy with Aidi Injection brings the benefit in the treatment of esophageal carcinoma. Aidi Injection might lessen the influence on immunity, adverse reaction of chemotherapy, and improve the activity of NKT cell.
出处
《中成药》
CAS
CSCD
北大核心
2013年第1期33-36,共4页
Chinese Traditional Patent Medicine
基金
山西省卫生厅科技攻关项目(20100130)
关键词
食管癌
艾迪注射液
化疗
免疫功能
NKT细胞
esophageal carcinoma
Aidi Injection
chemotherapy
immunological function
NKT cell
