摘要
目的分析高龄(≥80岁)男性股骨近端骨密度的独立相关因素,寻找提高其股骨近端骨密度的方法。方法测定442名高龄男性股骨近端骨密度,并检测血液生化、骨代谢和激素等指标,运用多元回归分析筛选高龄男性股骨近端骨密度的独立相关因素。结果高龄男性股骨近端骨密度的独立相关因素为慢性阻塞性肺疾病(β=-0.066,P=0.000)、Ⅰ型胶原羧基端肽β特殊序列(β=-0.189,P=0.000)、体重指数(β=0.008,P=0.008)和雌二醇水平(β=0.002,P=0.013)。结论积极防治慢性阻塞性肺疾病,降低血清Ⅰ型胶原羧基端肽β特殊序列水平,维持合理的体重指数和雌二醇水平,可能是提高高龄男性股骨近端骨密度的重要方法。
Objective To explore into the ways to improve proximal femur bone mineral density （PFBMD） by means of analysing independent associated factors of PFBMD in men aged 80 and over. Methods A cross-sectional survey was conducted comprising a sample of 442 men aged 80 and over. All of them underwent PFBMD measurement by dual energy X-ray absorptiometry and laboratory measurement. Univariate analyses and multivariate regression analyses were applied to discover independent associated factors of PFBMD. Results The finding of the study showed that independent associated factors of PFBMD included chronic obstructive pulmonary desease （ β= - 0. 066, P = 0. 000）, serum C-te- lopeptide of type 1 collagen （ CTX, β= - 0. 189, P = 0. 000）, body mass index （ β= 0. 008, P = 0. 002）, and serum estradiol （ β=0. 002, P =0. 013）. Conclusion The probable ways to increase PFBMD in men aged 80 and over are to prevent and cure chronic obstructive pulmonary desease, to decrease the concentration of serum CTX, keep a proper body mass index and the concentration of serum estradiol.
出处
《中华骨质疏松和骨矿盐疾病杂志》
2012年第4期255-258,共4页
Chinese Journal Of Osteoporosis And Bone Mineral Research
关键词
股骨
骨密度
男性
高龄
femur
bone mineral density
male
aged
