摘要
目的:总结CD44分子与胃癌临床病理特征及预后的关系,探讨CD44基因在胃癌发生发展中的作用。方法:应用PubMed及CNKI全文数据库检索系统,以"CD44、胃癌和肿瘤干细胞"等为关键词,检索2003-01-2012-07的相关文献,共检索到45篇文献,其中英文41篇,中文4篇。文献纳入标准:1)CD44分子的生物学特性;2)CD44与肿瘤干细胞的关系;3)CD44与胃癌发生、临床病理特征及患者预后的关系。根据纳入标准,符合分析的文献33篇。结果:CD44+细胞具有自我更新、多向分化、克隆球形成及体内成瘤等肿瘤干细胞/肿瘤起始细胞特性。CD44分子在胃癌组织的表达量显著高于癌旁正常组织,其表达水平越高,癌肿浸润越深,转移概率越大,患者预后越差,并与胃癌的组织类型具有相关性。结论:CD44能够介导胃癌的发生,促进癌细胞的侵袭和转移,其阳性表达影响患者预后,可能会为胃癌的早期诊断和靶向治疗提供新的科学依据。
OBJECTIVE：To summraize the the relationship between CD44 and clinical pathologic features,prognosis of gastric cancer,and explore the significance of CD44 in the occurrence and development of gastric cancer. METHODS： The fulltext database retrieval system of retrievaling PubMed and CNKI were searched. The words “CD44,gastric cancer, cancer stem cell（CSC）” were used as key words, to retrieval the literature about CD44 in the clinical pathologic features and prognosis of gastric cancer from 2003-01 to 2012-07, totally 45 literatures were selected,including 41 English and 4 chinese literatures. The including standard： 1）The biological characteristics of CD44;2）the relationship between CD44 and CSC; 3） the relationship between CD44 and clinical pathologic features, prognosis of gastric cancer. According to the above standard,totally 33 literatures were selected and analyzed. RESULTS： CD44＋ gastric cancer cells show the stem cell prop- erties of self-renewal, multiplex differentiation, spheroid coloning formation and tumorigenic ability in vivo. The expression of CD44 is demonstrated higher in the primary lesion of gastric cancer than that in normal tissue,its higher expressionis correlated with the severer infiltration depth,more metastasis occurences,poorer prognosis and histologic type. CONCLU- SIONS： CD44 plays an important role in the occurrence and development of gastric cancer,and then influences the clinical pathologic features,prognosis of patients. Therefore,such researches as the relation of CD44 with gastric cancer may pro- vide a new direction for early diagnosis,new drugs based on the targeted gene regarding to CD44.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第24期1911-1914,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
上海交通大学医学院科研基金(YZ1055)
上海市教委基金(12YZ047)
关键词
CD44
胃肿瘤
肿瘤干细胞
综述文献
CD44
gastric neoplasms
cancer stem cell（CSC）
review literature
