摘要
目的 探讨中西医结合治疗成人激素依赖性 (SD)原发性肾病综合征 (PNS)的临床疗效。方法 6 2例成人SD PNS分为治疗组和对照组。治疗组 31例用强的松和环磷酰胺 (CTX)并根据激素不同阶段加用中药 ,对照组 31例单纯用西药治疗。观察临床完全缓解率、复发率、缓解时间和不良反应。结果 治疗组完全缓解率为 74.2 % ,对照组为 38.7% ,有显著性差异 (P <0 .0 1) ;治疗组 1、2、4年的复发率为 0、4.4%、13% ,对照组为 8.3%、16 .6 %、41.6 % ,2组比较差异显著 (P <0 .0 5 ) ;治疗组平均缓解期为 (33.6± 3.9)月 ,对照组为 (13.4± 3.2 )月 ,治疗组显著长于对照组 (P <0 .0 1) ;治疗组不良反应为 32 .2 % ,对照组为87.1% ,治疗组显著低于对照组 (P <0 .0 1)。结论 中西医结合治疗方法能提高成人SD PNS的完全缓解率 ,减少复发和不良反应。
OBJECTIVE To study the clinical effects of integrated treatment of western medicine and TCM on adult hormone-dependent primary nephritic syndrome (AHDPNS). METHOD 62 cases of AHDPNS were divided randomly into the treatment group and the control group. In the treatment group, 32 cases were administered with prednisone and cytoxan (CTX) as well as Chinese herbs according to their different amounts of hormone at different phases. In the control group, only western medicine was applied to 31 cases. Then, their clinical complete remission rates, recurrence rates, remission times and adverse reactions were examined. RESULT The complete remission rate is 74.2% in the treatment group while 38.7% in the control group, which showed a noted difference ( P <0.01). The recurrence rates in the treatment group were 0, 4.4% and 13% in one , two and four years respectively while 8.3%, 16.6% and 41.6% in the control group accordingly. An obvious difference was observed between the two groups ( P <0.05). The mean remission time is(33.6±3.9)months in the treatment group while(13.4±3.2)months in the control group. The result suggests that the former is much longer than the latter ( P <0.01). The adverse reaction rate in the treatment group is 32.2%, which is far lower than 87.1% in the control group ( P <0.01). CONCLUSION The integrated treatment of western medicine and TCM can improve the complete remission rate in AHDPNS, reduce its recurrence rate and adverse reactions effectively.
出处
《南京中医药大学学报》
CAS
CSCD
2000年第4期209-211,共3页
Journal of Nanjing University of Traditional Chinese Medicine
基金
广东省中医药管理局资助项目! ( 972 42 )
关键词
激素依赖性
原发性肾病综合征
中西医结合治疗
integrated treatment of western medicine and TCM
adult
hormone dependent
primary nephritic syndrome
clinical study
