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富马酸喹硫平与利培酮治疗精神分裂症的对照研究 被引量:8

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摘要 目的比较富马酸喹硫平与利培酮治疗精神分裂症的疗效与安全性。方法将80例精神分裂症患者随机分为两组,每组各40例,分别给予富马酸喹硫平和利培酮治疗,疗程8周,采用阳性与阴性症状量表(PANSS),临床疗效总评量表(CGI-SI)、采用不良反应量表(TESS)评定疗效和不良反应。结果两组PANSS总分及CGI-SI评分均治疗前显著下降(P<0.01),富马酸喹硫平组显效率78%,利培酮组显效率75%两组疗效相仿(P>0.05).富马酸喹硫平组的嗜睡、体重增加的不良反应明显低于利培酮组(P<0.01),锥体外系反应、失眠、兴奋或激越与利培酮组相当,差异无统计学意义(P>0.05)。结论富马酸喹硫平组与利培酮组治疗精神分裂症的疗效相当。富马酸喹硫平组的不良反应较利培酮组少而轻,阿利哌唑的安全性高,依从性好。
作者 王尚红 任丽
出处 《中国实用医药》 2012年第35期139-140,共2页 China Practical Medicine
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  • 1赵靖平,朱荣华.奎的平:一种新的非典型抗精神病药[J].国外医学(精神病学分册),2000,27(1):36-39. 被引量:274
  • 2Wong JYM,et al.Eur Neurophychophamramacol 1996;6(suppl,3):38(abs p-2-5).
  • 3Wong JYM,Ewing BJ.Multiplc-dose pharmacokinctics of "Quetiapine"(quetiapine) in schizophrenic men and Women (Abstract.Schizophr Res 1997:24:200.(a).

二级参考文献15

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同被引文献53

  • 1甘照宇,张明,程敏峰,郑俩荣,张晋碚.双相障碍患者抗抑郁剂治疗中出现躁狂发作的回顾性研究[J].中国病毒病杂志,2010,12(3):207-209. 被引量:1
  • 2江开达.精神病学高级教程[M].北京:人民军医出版社,2011.
  • 3Lambert M, De Marinis T, Pfeil J, et al. Establishing remission and good clinical functioning in schizophrenia: predictors of best outcome with long-term risperidone long acting inject table treatment[J]. Eur Psychiatry, 2010,25(4): 220-229.
  • 4Macfadden W, Bossie CA, Turkoz I, et al. Risperidone long-acting therapy in stable patients with recently diagnosed schizophrenia[J]. Int Olin Psychopharmacol, 2010,25(2): 75-82.
  • 5Houthoofd S, Morrensm, Sabbe B. Cognitive and psy- chomotor effects of risperidone in schizophrenia and schizoaffec- tive disorder[J]. Clin Ther, 2008 , 30(9) : 1565-1589.
  • 6Castberg I, Spigseto. Serum concentrations of risperidoneand 9-hydroxyrisperidone after administration of the tong- actinginjectable form ofrisperidone: evidence from a routine therape uticdrugmonitoring service[J].TherDrugMonit,2005,27(1): 103-106.
  • 7傅灿莉,兰世安,赵天明.齐拉西酮治疗精神分裂症阴性症状40例[J].中国药业,2008,17(3):44-45. 被引量:7
  • 8Harvey PD,Bowie CR. Ziprasidone:Eficacy,tolerability, and emerging data on wide ranging efectiveness[J]. Expert Opin Pharmaeother,2005,6(2) :337-346.
  • 9Moller HJ, Riedel M,Jiiger M, et al. 'Short-term treatment with risperidone or haloperidol in first episode schizophre- niaS-week results of a randomized controlled trial within the German Research Network on Schizophrenia[J]. Int J Neuropsychophama Col, 2009,11 (7) : 985-997.
  • 10GaUhofer S, Paisey C, Roberts C, et al. Preferences, const mnts and work-lifestyle choices:The case offemale Scot- tish charter ed accountants[J]. Accounting Auditing&Ac- countability Journal, 2011,24 ( 1 ) : 440-470.

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