摘要
目的探讨乌司他丁对慢性阻塞性肺疾病急性加重期(AECOPD)患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及超氧化物歧化酶(SOD)的影响。方法 AECOPD患者随机分为两组,每组30例,两组常规治疗相同。治疗组在常规治疗基础上加用乌司他丁治疗,治疗前后观察血清TNF-α、IL-6及SOD的变化。结果随着治疗时间的延长,两组患者治疗后TNF-α、IL-6及SOD的水平均呈下降趋势,治疗组的TNF-α和IL-6下降较对照组明显,而SOD的活性较对照组高。结论乌司他丁可抑制AECOPD患者炎症因子和氧自由基,减轻AECOPD过度炎症反应及脂质过氧化引起的损伤。
Objective To investigate the effects of ulinastatin on serum TNF - α,IL -6 and SOD in patients with acute exacerbation of chronic obstructive pulmonary disease. Methods 60 patients with AECOPD were randomly divided into control group（30） and trial group（30）. Both groups received conventional therapy. The trial group received additional ulinastatin. The changes of TNF - α, IL - 6 and SOD were observed before and after treatment. Results With the time of therpy prolonged, TNF -α, IL - 6 and SOD showed a downtrend. In trial group, TNF -α and IL - 6 decreased more obviously than control group. But the activity of SOD in trial group was higher than in control group. Conclusion Ulinastatin can inhibit inflammatory ihctors and oxyradica, and relieve the injury induced by excess inflammatory reaction lipid peroxidation in patients with AECOPD.
出处
《临床和实验医学杂志》
2013年第2期111-112,共2页
Journal of Clinical and Experimental Medicine
