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布林佐胺合成路线图解 被引量:2

Graphical Synthetic Routes of Brinzolamide
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摘要 布林佐胺(brinzolamide,1),化学名为(R)-(+)-4-乙胺基-2-(3-甲氧基丙基)-3,4-二氢-2H-噻吩并[3,2-e]-1,2-噻嗪-6-磺酰胺-1,1-二氧化物,是美国爱尔康公司研发的杂环磺胺类青光眼治疗药物,1998年在美国获准上市,商品名为Azopt。
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2013年第1期95-97,共3页 Chinese Journal of Pharmaceuticals
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参考文献10

  • 1姚忠,江程,李津申,胡建强,尤启冬.用作抗青光眼药物的碳酸酐酶抑制剂[J].药学进展,2002,26(4):202-205. 被引量:6
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  • 3Conrow RE, Dean WD, Zinke PW, et al. Enantioselectivesynthesis of brinzolamide (AL-4862) , a new topicalcarbonic anhydrase inhibitor. The DCAT Route tothiophenesulfonamides [J]. Org Process Res Dev, 1999,3(2):114-120.
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  • 8Govind SD, Venkatasubramanian TR, Baban BN, et al.Improved process for the preparation of (R) (+) -4-(ethylamino) -3,4-dihydro-2- (3-methoxypropyl) -2H-thieno [3,2-e] -1,2-thiazine-6-sulfo-namide-l, 1 -dioxide: WO,2008062463 [P]. 2007-10-12.
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二级参考文献12

  • 1Mclanghlin M Chiou G C.抗青光眼药物近代发展概况[J].国外医学:药学分册,1986,13(1):54-57.
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  • 7Silver L,Brinzolamide Dose Response Study Group.Surv Ophthalmol,2000,44:S147
  • 8Sall K,Brinzolamide Primary Therapy Study Group.Surv Ophthalmol,2000,44:S155
  • 9Shin D,Brinzolamide Adjunctive Therapy Study Group.Surv Ophthalmol,2000,44:S163
  • 10Silver LH,Brinzolamide Comfort Study Group.Surv Ophthalmol,2000, 44:S141

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