摘要
目的:探讨盐酸文拉法辛缓释片治疗广泛性焦虑患者的疗效及安全性。方法:将60例患者随机均分为盐酸文拉法辛缓释片组(研究组)与盐酸舍曲林组(对照组)各30例,疗程为4周,于治疗前及治疗1、2、4周末采用汉密尔顿焦虑量表(HAMA)和CGI-BP评定临床疗效,副反应量表(TESS)评定不良反应。结果:治疗4周末,研究组显效率76.7%,对照组70.0%,两组总体疗效相当(P>0.05)。汉密尔顿焦虑量表评分,两组总分均有显著下降(P<0.01),但研究组治疗2周末较对照组下降显著(P<0.05),其它时点评分均无显著性差异(P>0.05)。文拉法辛组的不良反应发生率为23.3%(7/30),盐酸舍曲林组为33.3%(10/30),差异无统计学意义(P>0.05)。结论:盐酸文拉法辛缓释片治疗广泛性焦虑疗效显著,安全性高,依从性好,且盐酸文拉法辛缓释片起效更快,但高血压患者应慎用。
Objective：To investigate the Venlafaxine-xr tablets in the treatment of the efficacy and safety of the patients with generalized anxiety. Methods ： Randomized controlled study of the 60 patients enrolled, 30 cases of the Venlafaxine-xr tablets group （study group） and sertraline hydrochloride group （control group） 30 cases for 4 weeks. At the pre-treatment and treatment of 1,2,4 weekend using theHamilton Anxiety Scale （HAMA） and CGI-BP to evaluate the efficacy, side effects scale （TESS） assessment of adverse reactions. Results：4 weeks after treatment, the study group was 76.7 % in the control group to 70 %, the two groups overall treatment （P〉0.05）. The the Hamilton anxiety table rated the two groups total score were significantly decreased （P〈0.01） ,but the research group therapy the 2 weekend compared with the control group decreased significantly （P〈0.05）, the other points score had no significant difference （P〉0.05） . Venlafaxine group,incidence of adverse reactions was 23.3% （7/30） ,the sertraline hydro- chloride Group was 33.3 % （10/30）, the difference was not statistically significant （P〉0.05）. Conclusion： Venlafaxine-xr tablets in the treatment of generalized anxiety efficacy significantly, high safety,good compliance and Venlafaxine-xr tablets faster onset, but should be used with caution in patients with hypertension.
出处
《亚太传统医药》
2013年第1期147-148,共2页
Asia-Pacific Traditional Medicine
