摘要
[目的]探讨脑钠肽（BNP）在妊娠高血压性心脏病患者中的表达及其意义。[方法]运用化学发光免疫分析1227例妊娠期高血压综合症（妊高症）患者和1339例正常妊娠妇女血浆BNP水平，比较妊高症患者与正常妊娠妇女、妊高症无心脏病患者与并发心脏病患者血浆BNP水平，分析BNP水平与临床参数的关系。[结果]妊高症患者血浆BNP水平明显高于正常妊娠妇女（P〈0．01）；妊高症患者中，心脏病患者BNP水平显著高于无心脏病患者（P〈0．05）；BNP水平与妊娠高血压性心脏病患者的年龄、孕周、经产与否、胎数无关，与患者心功能分级密切相关（P〈0．01）。[结论IBNP在妊娠高血压性心脏病的诊断与病情评估中发挥重要作用，可作为潜在的生物靶点。
][Objective] To explore the expression of brain natriuretic peptide（BNP） in patients with gesta- tional hypertensive heart disease and its significance. [Methods] Chemiluminescence immunoassay was used to analyze plasma BNP in 1227 patients with gestational hypertension and 1339 normal pregnant women. Plasma level of BNP was compared among patients with gestational hypertension, normal pregnant women, gestational hypertension patients without heart disease and gestational hypertension patients with heart disease. The cor- relation between BNP and clinical parameters was analyzed. [Results]BNP in patients with gestational hyper- tension was higher than that in normal pregnant women（ P d0.01）. Among gestational hypertension patients, BNP in patients with heart disease was higher than that in patients without heart disease（ P d0.05）. There was no relationship between BNP and age, gestational weeks, multiparity and embryo number. But BNP was related with cardiac functional grading. [Conclusion] BNP plays an important role in the diagnosis and condition prediction of gestational hypertensive heart disease, and can be used as the potential biological target.
出处
《医学临床研究》
CAS
2012年第12期2370-2371,共2页
Journal of Clinical Research
关键词
高血压
并发症
妊娠并发症
心血管
病理学
利钠肽
脑
分析
hypertension/CO
pregnancy complications, cardiovascular/PA
natriuretic peptide, brain/AN
