摘要
目的观察替米沙坦对高血压并糖尿病患者血管紧张素转换酶2（ACE2）mRNA表达的影响。方法62例高血压并糖尿病患者随机分为常规治疗组和替米沙坦组，测定各组用药前后外周血单核来源巨噬细胞ACE、ACE2mRNA的表达。结果（1）各组治疗4、12周后血压均降低，替米沙坦组降压效果强于常规治疗组（P〈0．05）；（2）治疗12周后替米沙坦组糖化血红蛋白下降较常规组明显，但差异无统计学意义（P〉0．05）；（3）治疗12周后替米沙坦组ACE2含量较常规治疗组明显增高[（23．9±8．2）U／L比（16．3±8．9）U／L，P〈0．05]，ACE2mRNA表达较常规治疗组明显增高（0．73±0．06比0．51±0．04，P〈0．01）。结论替米沙坦对高血压并糖尿病患者降压、改善糖代谢的作用部分是通过增加ACE2活性及基因表达所致。
Objective To investigate the effects of telmisartan on the expression of angiotensin converting enzyme2 （ ACE2 ） mRNA in monocyte-derived macrophages of hypertensive patients eompanied with diabetes. Methods 62 essential hypertensive patients companied with diabetes were randomly divided into two groups： regular treatment group, and telmisartan group. Then the content of ACE and ACE2 in serum was detected by ELISA, and the expression of ACE mRNA and ACE2 mRNA in monocyte-derived macrophages of patients was detected by RT-PCR before and after having been treated. Results （ 1 ） After having been treated for 4 weeks and 12 weeks, the blood pressure of the patients in two groups were decreased significantly, Comparing with regular group, telmisartan group seemed to have more obvious therapeutic effect （P 〈 0. 05 ） ; （2）After having been treated for 12 weeks, glycosylated hemoglobin diseased in both group, but there was no significant difference between the two group （ P 〉 0.05 ） ; （ 3 ） In telmisartan group, the content of ACE2 in serum was increased after having been treated for 12 weeks than that in regular treatment group, [ （ 23.9 ± 8. 2） U/L vs （ 16. 3 ± 8.9 ） U/L, P 〈 0.05 1 ; and the expression of ACE2 mRNA in monocyte-derived macrophages in telmisartan group was obviously increased after 12 weeks comparing with regular treatment group （0. 73 ± 0. 06 vs 0. 51± 0. 04,P 〈 0. 01 ）. Conclusion The role of telmisartan in decreasing blood pressure and it＇s advantage to the metabolism of glucose are partly related with the up-regulation of ACE2 mRNA.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2013年第1期26-29,共4页
Chinese Journal of Internal Medicine
基金
陕西省科技攻关项目[2007K13-03（13）]
关键词
血管紧张素转换酶抑制药
高血压
糖尿病
Angiotense-converting enzyme inhibitors
Hypertension
Diabetes mellitus
