摘要
血管能抑素是继血管生成抑制素、内皮抑素之后新发现的一种血管生成和肿瘤生长抑制因子。动物实验研究结果显示,血管能抑素通过抑制血管生成、阻断肿瘤生长的营养供应,从而抑制了多种肿瘤细胞的生长和转移。近年来因其具有良好的抗肿瘤血管生成活性而倍受关注,成为抗肿瘤治疗研究的新热点之一。本文就其作用机制尤其是在肿瘤治疗中的应用现状及研究进展进行综述和展望。
After the discovery of Angiostatin and Endostatin, Canstatin is a new inhibitor that can inhibit angiogene- sis and the tumor growth. Results of animal experiments demonstrated that Canstatin has the inhibiting effects of angio- genesis and tumor cells nutrition, and then to inhibit the growth and metastasis of tumors. Therefore, it becomes a new research hotspot of antineoplastic therapy as concerned of it has good activity of anti - tumor angiogenesis. The anti - tumor mechanism of Canstatin and its research status of application are summarized and prospected in this re-
出处
《现代肿瘤医学》
CAS
2013年第1期194-197,共4页
Journal of Modern Oncology
基金
国家自然科学基金资助项目(编号:81060174)
