摘要
肿瘤干细胞学说认为,肿瘤组织中存在一小部分具有无限增殖、自我更新、放化疗耐受以及高致瘤能力等干细胞特性的肿瘤干细胞(cancer stem cells,CSCs),它们是肿瘤无法治愈并不断进展的重要原因。微小RNA(microRNAs,miRNAs)是一类短链非编码RNA,通过降解mRNA或抑制mRNA翻译的方式调控着众多基因的表达。研究显示,miRNA在多种肿瘤的CSCs中异常表达,CSCs的恶性表型维持需要众多miRNA的参与。近年来,靶向miRNA的CSCs治疗实验研究已经初步展现出良好的安全性和疗效。针对miRNA的治疗策略将成为CSCs治疗的一个新的研究方向,最大限度地清除CSCs将使治愈肿瘤逐渐成为可能。
CSCs （cancer stem cells） theory suggests that CSCs are a small subpopulation of cells within tumors that possess characteristics associated with unlimited proliferation, self-renew, radiotherapy and chemotherapy resistance and high tumorigenic ability. Furthermore, CSCs are considered the main source of malignant tumors which become incurable or progress continuously, miRNAs （microRNAs） are a class of short non-coding RNAs that act as master regulators of gene expression through mRNA cleavage or translational repression. Studies indicated that numerous miRNAs are abnormally expressed in CSCs in a variety of tumors. Moreover, the maintenance of CSCs＇ malignant phenotype also needs the participation of miRNAs. Recently, experimental studies have demonstrated high safety and efficacy of miRNA as a therapeutic target in the treatment of CSCs. Therefore, the therapeutic strategies targeting miRNA may kill CSCs in maximum and even allow a ＂cure＂ for tumors, and this will introduce a new area of research on CSCs therapy.
出处
《肿瘤》
CAS
CSCD
北大核心
2013年第1期97-102,共6页
Tumor
关键词
肿瘤
肿瘤干细胞
微RNAS
Neoplasms
Neoplastic stem cells
MicroRNAs
