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长链非编码RNA HOTAIR在肿瘤发生中的研究进展 被引量：4

Research advances of long non-coding RNA HOTAIR in the development of human carcinomas
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摘要 长链非编码RNA以RNA的形式在多个层面(表观遗传学、转录水平、转录后水平)上调控基因的表达,在个体发育及肿瘤的发生、发展过程中起着重要的作用。近来研究表明长链非编码RNA HOTAIR(lnc-HOTAIR)在多种肿瘤中表达上调,与肿瘤的发生、发展、转移和预后等密切相关,成为肿瘤研究的新热点。本文结合国内外最新报道,对lnc-HOTAIR在各种肿瘤中的研究进展作一综述。 Long non-coding RNAs regulate gene expression at the levels of epigenetic, transcriptional and post-transcriptional processing, playing an important role in individual development, tumorigenesis and progression. Recently, overexpression of long non- coding RNA HOTAIR（lnc-HOTAIR） has been found in various human cancers and accumulating evidences have showed the significant relationship between lnc-HOTAIR and tumorigenesis, development, metastasis and prognosis. In this review, we summarize the latest progresses, both domestic and overseas, on the research of lnc-HOTAIR in various human carcinomas.
作者 刘志利 王朝霞
机构地区 南京医科大学第二附属医院肿瘤科
出处 《临床肿瘤学杂志》 CAS 2012年第12期1132-1135,共4页 Chinese Clinical Oncology
基金 国家自然科学基金资助项目(30973477) 江苏省自然科学基金资助项目(BK2010590) 江苏省医学重点人才基金资助项目(RC2011080)
关键词 长链非编码RNA HOTAIR 肿瘤 Long non-coding RNA HOTAIR Carcinoma
分类号 R730 [医药卫生—肿瘤]
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参考文献28

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同被引文献51

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临床肿瘤学杂志
2012年 第12期

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