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不同产地雄黄及其炮制品中二硫化二砷和可溶性砷含量比较 被引量:9

Comparative Study on Contents of As_2S_2 and As_2O_3 in Realgar and Processed Products
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摘要 目的:比较研究不同产地雄黄及其炮制品中主成分As2S2及可溶性砷盐As2O3的含量差异。方法:采用2010年版《中国药典》雄黄项下的滴定法测定不同产地雄黄及其炮制品中As2S2的含量,采用AFS-230E型原子荧光光度计检测上述样品中可溶性砷盐As2O3含量。结果:不同产地的雄黄及其炮制品中As2S2,As2O3含量存在显著差异。雄黄炮制后,炮制品中As2S2含量均提高,As2O3含量均明显降低。除吉林和江苏2个产地的的雄黄及其炮制品中As2S2含量<90.0%,其余样品均符合药典规定;且雄黄炮制品中As2O3含量均能控制在1.7 mg.g-1以下。结论:研究结果可为指导雄黄临床合理用药提供参考依据。 Objective: To study the content difference of the principal component (As2S2 ) and the soluble arsenic salt (As2O3 ) in realgar and it processed products from different origins. Method: As2S2 content was determined by titration based on the analysis method of realgar recorded in Chinese Pharmacopoeia (2010 edition), and As2O3 content was detected using AFS-230E Atomic fluorescence speetrophotometer. Result: The contents of As2S2 and As2O3 were significantly different in realgar and its processed products from different origins. After processing, A%S2 content in the processed products was obviously increased, while A%03 content was significantly reduced. Except that As2S2 content in realgar and its processed products from Jilin province and Jiangsu province was less than 90. 0% , the rest of the samples can meet the pharmacopoeia requirements, and As2O3 content in all of the processed products can be controlled below 1.7 mg ·g-1. Conclusion: This findings can provide a reference for guiding rational clinical applications of realgar.
出处 《中国实验方剂学杂志》 CAS 北大核心 2013年第2期49-52,共4页 Chinese Journal of Experimental Traditional Medical Formulae
基金 国家"重大新药创制"科技重大专项(2009ZX09301-005) 国家科技部科研院所基础研究专项基金(2002DEB20067) 国家"十一五"科技支撑计划项目(2006BAI55B02-03)
关键词 雄黄 二硫化二砷 三氧化二砷 含量测定 realgar As2S2 As2O3 content determination
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