摘要
目的探讨血管内皮细胞生长因子(VEGF)和糖类抗原(CA153)在乳腺癌患者血清中的表达及其与疾病进展的关系。方法检测30例乳腺癌患者、30例乳腺良性疾病患者和60例健康女性血清中VEGF、CA153的水平,对乳腺癌患者采用1997年国际抗癌联盟(UICC)公布的乳腺癌TNM分类法进行分期,并将乳腺癌患者以有无淋巴结转移分为2组,记录VEGF、CA153检测结果,用ELISA法检测VEGF,用电化学发光法检测CA153。结果乳腺癌组各项检测指标与乳腺良性疾病组和健康对照组比较差异均有统计学意义(P<0.01),而乳腺良性疾病组与健康对照组比较差异无统计学意义(P>0.05);乳腺癌患者Ⅲ期与Ⅰ期、Ⅱ期比较VEGF、CA153水平差异均有统计学意义(P<0.01);淋巴结转移乳腺癌患者有与无淋巴结转移者的血清VEGF、CA153水平比较差异有统计学意义(P<0.01)。结论联合检测血清VEGF、CA153水平对乳腺癌的诊断、病情评估、预后判断有重要价值。
Objective To study the relationship between the expression of VEGF and CA153 and the progression of breast cancer.Methods The expression of VEGF and CA153 in 30 patients with breast cancer,30 patients with benign breast diseases and 60 healthy women was detected.The breast cancer patients were divided into three periods according to the TNM classification of breast cancer which was published by UICC in 1997 and were detected into two groups with lymphatic metastasis or not,respectively.The levels of VEGF and CA153 were recorded.VEGF was detected by ELISA and CA153 was detected by chemoluminescence method.Results The levels of VEGF and CA153 were significantly different（P0.01） in breast cancer groups,benign breast diseases group and healthy group.There was no statistical significance（P0.05）in benign breast diseases group and healthy group.The levels of VEGF and CA153 were significantly different（P0.01） between Ⅲ stage and Ⅰ and Ⅱ stage.There was statistical difference（P0.00） between breast cancer patients with lymphatic metastasis or not.Conclusion The joint detection of VEGF and CA153 could be used as an important reference index for the diagnosis,evaluation and prognosis of breast cancer.
出处
《国际检验医学杂志》
CAS
2013年第2期147-148,共2页
International Journal of Laboratory Medicine
