摘要
目的建立我国部分地区8—10岁学龄儿童的甲状腺激素及促甲状腺素（TSH）参考值范围，为学龄儿童甲状腺疾病的临床诊治、预防监测以及相关研究提供参考。方法在6个碘盐供应较好的省市一次性横断面调查8～10岁学龄儿童，通过统一设计的调查表以及实验室检测结果严格筛选出664名正常学龄儿童进入甲状腺激素及TSH参考值范围的建立；甲状腺激素及TSH测定采用Bayer公司的化学发光免疫测定方法，参考值范围采用95％区间范围表示。结果建立正常学龄儿童的甲状腺功能指标参考值范围TSH为1．03—8．42mlU／L、FT4为13．44—20．59pmol／L、FT3为4．75～6．96pmol／L、n为75．29～152．66nmol／L、TT3为1．76-3．35nmol／L；在不同性别间上述各项指标无统计学差异；不同年龄间进行比较，仅有8岁儿童TT4略高；农村与城市问比较发现，农村儿童TSH、TT3高于城市儿童（均P〈0．01），而FT4略低于城市儿童（P〈0．05）。结论学龄儿童的甲状腺激素及TSH水平与成人有明显差异，单独建立儿童甲状腺功能指标的参考值范围对学龄儿童甲状腺疾病的临床诊治及预防监测非常重要。
Objective To set up the reference range for thyroid hormones and thyrotropin （TSH） of 8-10 years old school children in certain regions of China to provide reference criteria for diagnosis, treatment, and monitoring of thyroid diseases and related research. Methods A cross-sectional survey was conducted in primary school children aged 8-10 years from six iodine sufficient areas. 664 normal school children were selected for establishing reference ranges of thyroid hormones and TSH after crucial screening through questionnaire and laboratory investigation. The serum hormone levels were determined by using chemilumineseent immunoassay （Bayer＇s reagents） , and the reference range of each hormone was displayed as its 95% central interval. Results The reference ranges of TSH, FT4 , FT3 , TT4, and TF3 were 1.03-8.42 mIU/L, 13.44-20.59 pmol/L, 4.75-6.96 pmol/L, 75. 29-152.66 nmol/L, and 1.76-3. 35 nmoL/L, respectively. There was no significant difference in hormone levels between boys and girls. The eight years old group had slightly higher TY4 level compared with the other age groups. The rural children had higher TSH and TF3 levels and lower FT4 level than the urban children. Conclusion The thyroid hormone and TSH levels are substantially different between school children and adults. Therefore, it is necessary to establish the reference range of thyroid function indices for normal school children in order to diagnose, treat, and monitor thyroid diseases.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2013年第1期42-45,共4页
Chinese Journal of Endocrinology and Metabolism
基金
国家“十一五”支撑计划资助项目（2006BA106805）
