摘要
目的观察高原脐贴软膏贴脐对急性高原反应(acute mountain sickness,AMS)的预防效果。方法将62例健康青年男性汽车兵按随机数字表法分为观察组和对照组(n=31)。自海拔1 392 m,历时5 d急进到海拔4 617 m的高原。出发前1 d开始,分别予受试者高原脐贴软膏、安慰剂软膏贴脐,膏药每天一换,连续5 d。在出发后定期测定受试者心率(HR)、血压(BP)和血氧饱和度(SaO2),并以军用卫生标准GJB1098-91《急性高原反应的诊断和处理原则》制订的《高原临床症状自测问卷表》及《高原急性胃肠应激反应自测评分表》随访记录受试者AMS症状和胃肠道症状;用《不良事件报告表》随访记录受试者的不良反应。结果急进高原后,观察组胃肠应激反应症状评分和发生率均低于对照组(P<0.01);观察组第1天的AMS发生率低于对照组(P<0.05),第3、5天的AMS症状评分和发生率均低于对照组(P<0.01);观察组第1天的血压和第5天的心率低于对照组(P<0.05),第5天的SaO2高于对照组(P<0.05);试验期间无不良反应发生。结论高原脐贴软膏贴脐对急性高原反应有明显的预防效果。
Obiective To observe the effect of umbilicat therapy w,tn atuplano navel balm,an ointment based on a traditional Chinese prescription ＂Xiaochaihu Decoction＂, against acute mountain sickness （AMS）. Methods Sixty-two young fit male automotive soldiers, were randomly divided into 2 groups, who were respectively treated by altiplano navel balm （ treatment group, n = 31 ） and placebo （ control group, n = 31 ）. The altiplano navel balm or placebo （one piece per day, for 5 consecutive days） was given to stick umbilical region in the 2 groups respectively in 1 d before departure. Then, they began to move from the altitude 1 392 m and arrived at the altitude 4 617 m on the fifth day. Since departure, their heart rate （ HR）, blood pressure （BP） and arterial oxygen saturation （SaO2） were determined regularly. The symptoms of AMS and the gastrointestinal symptoms were observed according to the State Military Standard GJB1098-91 ＂Princi- ples of diagnosis and treatment of benign form of acute mountain sickness＂ and ＂Plateau acute gastrointestinal stress reaction self-test rating scale＂. All adverse reactions were recorded with ＂the adverse events report form＂. Results Acute gastrointestinal stress reaction scores and occurrence rate of gastrointestinal symptoms were both significantly lower in treatment group than in control group （P 〈0.01 ）. In the 1st day, the occur-fence rate of AMS was lower in treatment group than control group （P 〈 0.05 ）. In the 3rd and 5th days, the degree of AMS and occurrence rate of AMS were significantly lower in treatment group than control group （ P 〈 0. 01 ）. In the 1st day, BP was lower in treatment group than control group（P 〈0. 05 ）, and in the 5th day, HR was lower in treatment group than control group （P 〈 0.05 ）, while SaO2 of treatment group was significant- ly higher than that of control group （P 〈 0.05 ）. During the experiment, none of adverse events happened in the 2 groups. Conclusion Umbilical therapy with altiplano navel balm exerts remarkable effect to prevent AMS.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2013年第3期251-254,共4页
Journal of Third Military Medical University
基金
军队中医药专项重点课题(2010ZYZ134)~~
关键词
高原病
中医治法
预防和防护用药
altitude sickness
therapeutic methods
protective agents
