摘要
目的:通过检测口腔黏膜下纤维性变(OSF)组织中TLR2的表达情况,初步探讨TLR2在OSF发病中的作用。方法:选取OSF患者30例(早、中、晚期各10例)为实验组,正常者5例为对照组,每例研究对象取其口腔颊黏膜,采用免疫组化SABC法检测各组织中TLR2的表达情况。结果:正常口腔颊黏膜组织中TLR2呈阳性表达,在OSF组织中TLR2表达明显增强(P<0.05),主要表达于黏膜下组织;OSF早、中、晚期组织中TLR2的表达无显著性差异(P>0.05)。结论:与正常口腔黏膜相比,OSF组织中TLR2的表达增高,提示TLR2在OSF发病中起一定的促进作用。
Objective：To investigate the expression and distribution of TLR2 in OSF,and further discuss its possible role in pathology of OSF.Method：The SABC immunohistochemistry was used for detecting the expression and distribution of TLR2 in tissues of 5 normal controllers and 30 patients suffered from OSF（10 cases of early,intermediate and advanced stage,respectively）.Result：A positive expression of TLR2 was detected in normal oral mucosa,and a significant increasing of expression could be found in OSF（P 0.05）.The expression of TLR2 in OSF was mainly detected in submucosal connective tissues.And there was no significant difference between each stage of OSF in the expression of TLR2（P 0.05）.Conclusion：Comparing with the normal oral mucosa,the expression of TLR2 was significantly increased in OSF tissues.It indicated that TLR2 may contribute to the pathogenisis of OSF.
出处
《临床口腔医学杂志》
2013年第1期17-19,共3页
Journal of Clinical Stomatology
