摘要
目的探讨pT3期高、中分化肠型胃癌中肿瘤出芽与淋巴结转移和淋巴管侵犯之间的关系。方法分别应用HE和免疫组化EnVision法对84例pT3期高、中分化肠型胃癌有无肿瘤出芽进行判断。结果 HE染色下肿瘤出芽发生率为52.4%(44/84),与免疫组化染色的59.5%(50/84)相仿(P>0.05)。肿瘤出芽在有淋巴管侵犯和淋巴结转移者的pT3期肠型腺癌的出芽率分别为69.6%和71.1%,明显高于无淋巴管侵犯的39.3%和无淋巴结转移者的46.2%(P<0.05);随着阳性淋巴结数目增多,高度肿瘤出芽也越多(P<0.05)。高度肿瘤出芽与淋巴管侵犯密切相关(P<0.05)。结论应用CKpan免疫染色有助于判断pT3期胃肠型腺癌肿瘤出芽;肿瘤出芽检测可有助于预测pT3期胃肠型腺癌淋巴结转移。
Objective To metastasis and lymphatic invasion study the relationship between tumor budding and lymph node in intestinabtype gastric ad of pT3 stage. Methods The evaluation of tumor budding in 84 cases with pT3 stage intestinabtype adenocarcinoma was performed by HE and immunohistochemical EnVision techques. Results The positive rate of tumor budding reported by HE staining was 52. 4% （44/84）, which was similar to 59.5 % （50/84） reported by immunohistochemistry. The positive rates of tumor budding in pT3 stage intestinal-type adenocarcinoma with lymphatic invasion and lymph node metastasis were 69.6% and 71.1%, respectively, which were higher than 39.3% in that without lymphatic invasion and 46.2% in that without lymph node metastasis（P^0.05）. The more the number of positive lymph nodes, the more the high-degree tumor budding. High-degree tumor budding was closely related to lymphatic invasion （P〈0. 05）. Conclusion CKpan immunostaining is helpful in evaluating tumor budding of pT3 stage intestinal-type gastric adenocarcinoma. The detection of tumor budding can help to predict lymph node metastasis of pT3 stage gastric adenocarcinoma.
出处
《江苏医药》
CAS
北大核心
2013年第1期21-24,F0002,共5页
Jiangsu Medical Journal
基金
江苏省卫生厅科研基金(H200744)
关键词
肠型胃癌
肿瘤出芽
Gastric adenocarcinoma of intestinal-type
Tumor budding
