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HPA轴功能紊乱与糖尿病认知功能障碍 被引量：2

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摘要 2型糖尿病已成为一种常见病，其患病率的增长速度惊人。2010年国内的流行病学调查表明年龄标准化的糖尿病患病率为9．7％[1]。。随着研究的深入，糖尿病与认知功能的关系越来越受到人们的重视。多项研究均表明糖尿病病人与非糖尿病病人相比认知功能下降明显，糖尿病病人发生认知功能损害及痴呆的危险性显著增加[2,3]。
作者 古文娟 张孟仁
机构地区 中国医学科学院/北京协和医学院北京协和医院
出处 《医学研究杂志》 2013年第1期187-189,共3页 Journal of Medical Research
关键词 2型糖尿病 认知功能障碍 功能紊乱 HPA轴 糖尿病患病率 非糖尿病病人 认知功能下降 认知功能损害
分类号 R587.1 [医药卫生—内分泌]
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参考文献16

  • 1Yang W,Lu J,Weng J. Prevalence of diabetes among men and women in China[J].New England Journal of Medicine,2010,(12):1090-1101.
  • 2Okereke OI,Kang JH,Cook NR. Type 2 diabetes mellitus and cognitive decline in two large cohorts of community-dwelling older adults[J].J Am Geriattr Soc,2008,(06):1028-1036.
  • 3Verdelho A,Madureira S,Moleiro C. White matter changes and diabetes predict cognitive decline in the elderly:the LADIS study[J].Neurology,2010,(02):160-167.
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  • 10Alexis MS,Thiruma VA,Roy GC. Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons[J].Nature Neuroscience,2008,(03):309-317.doi:10.1038/nn2055.

同被引文献37

  • 1张炜,汤正义,黄昉,王卫庆,张毅,李小英,赵咏桔,胡仁明,宁光.诊断库欣综合征时多种检查方法的比较[J].中华内分泌代谢杂志,2005,21(5):402-404. 被引量：39
  • 2杨艳青,沈鸿敏,李建业,郝桂敏.高泌乳素血症患者外周血淋巴细胞亚群、白细胞介素-2及皮质醇的变化[J].生殖医学杂志,2006,15(2):84-87. 被引量：1
  • 3陈灏珠.实用内科学[M]11版[M].北京:人民卫生出版社,2000.1393.
  • 4Choibh, Kimcg, Limy, et al. Curcumin down - regulates the multidrug -resistance mdrlb gene by inhibiting the PI3K/Akt/NFkappa B path- way [ J ]. Cancer Lett,2008,259 ( 1 ) : 111 - 118.
  • 5Rosmond R. Stress induceddisturbances of the HPAaxis : a pathway to type 2 diabetes? [ J ]. Med Sci Monit,2003,9 (2) : RA35.
  • 6Chan O, Chan S, Inouye K,et al. Diabetes impairs hy pothalamic pi- tuitary adrenal(HPA) responses to hypoglycemia, and insulin treat- ment normalizes HPA but not epinephrine responses [ J ]. Diabetes, :2002,51 (2) : 1681.
  • 7Vestergaard H,Bratholm P,ChristensenNJ. Increments in insulin sensitiv- ity during intensive treatment are closely correlated with decrements in glucocorticoid receptorm RNA in skeletal muscle from patients with Type&diabetes [ J ]. Clin Sciclond ,2001,101 ( 5 ) :533 - 540.
  • 8Han JS,Bizon JL,Chun I-IJ,et al. Decreased glueccorticoid receptor mR- NA and dysfunction of HPA axis in rats after removal of the cholinergic innervation to hippocampus[J]. Eur Neuresci,2002,16(7):1399.
  • 9Den Heijer T,Vermeer SE,van Dijk EJ ,et al. Type 2 diabetes and atrophy of mediahemporal lobestructures onbrain MRI [ J ]. Dia - betologia,2003,46 (12) :1604-1610.
  • 10Gold SM,Dziobek I,Sweat V,et al. Hippocampal damage and memory im- pairments as possible early brain complications of type 2 diabetes[J]. Dia- betologia,2007,50(4) :711 -719.

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医学研究杂志
2013年 第1期

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