摘要
目的观察降脂合剂对高脂血症大鼠血脂谱、血液流变学的影响。方法将雄性Wistar大鼠60只随机等分为正常对照组、模型组、辛伐他汀组和降脂合剂高、中、低剂量组,正常对照组用基础饲料喂养,其余各组喂高脂饲料建立高脂血症大鼠模型,造模的同时预防给药,10周后测定各组动物血脂谱、低密度脂蛋白(LDL-C)氧化易感性及血液流变学指标。结果与模型组比较,降脂合剂各剂量组胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、载脂蛋白B(ApoB)的水平降低,高密度脂蛋白(HDL-C)、载脂蛋白A(ApoA)的水平及apoA/apoB比值升高,差异均有统计学意义(P<0.05或P<0.01);降脂合剂各剂量组最大氧化速率时间(Tmax)和LDL氧化延迟时间(Lag time)均明显延长,差异均有统计学意义(P<0.05或P<0.01)。与模型组比较,降脂合剂各剂量组血浆黏度(ηp)、全血黏度(ηb,低、中、高切)、红细胞聚集指数(IEA)、红细胞压积(HCT)明显降低,红细胞电泳时间(EET)明显缩短,红细胞变形指数(IED)升高,差异均有统计学意义(P<0.05或P<0.01)。结论降脂合剂能够调节实验性高脂血症大鼠血脂代谢及血液的黏、浓、聚、凝状态,明显降低高脂血症大鼠LDL氧化易感性,对血脂和血流异常有较好的调节和治疗作用。
Objective To observe the effect of Jiangzhi mixture on blood lipid profile and hemorheology of hyperlipi- demia rats. Methods Sixty male Wistar rats were randomly divided into six groups, the normal control group, model group, simvastatin group, and high-, middle-, low-dose Jiangzhi mixture groups. The normal control group was fed with routine forage, and the other groups were fed with high fat forage for the establishment of hyperlipidemia model. During the modeling, the rats were given the corresponding drugs. After 10 weeks, we measured blood lipid profile and blood hemorheology of each rat. Results After treatment, serum total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol（LDL-C）, apolipoprotein B（ApoB） levels were decreased, and high density lipoprotein （ HDL-C ）, apolipoprotein A （ApoA） levels and apoA / apoB ratio were increased in Jiangzhi mixture groups, the differences being statistically significant（P 〈 0.05 or P 〈 0.01 compared with the model group）. Jiangzhi mixture also had obvious effect on prolonging the time for arriving maximum oxidation rate（Tmax） and LDL oxidation lag time（ Lag time）, decreasing plasma viscosity（qP）, low-, medium-, and high-shear whole blood viscosity （ηb）, index of erythrocyte aggregation（IEA）, hematocrit（HCT）, erythrocyte electrophoresis time（EET）, and increasing the index of erythrocyte deformability（IED）, 0.01 compared with the model group）. Conclusion the differences being statistically significant（P 〈 0 Jiangzhi mixture can modulate blood lipid metabolism the viscosity, aggregation, and coagulation of hemorrheology, and reduce LDL susceptibility to oxidation mental hyperlipidemia rats, showing certain therapeutic effect on hyperlipidemia rats. .05 or P 〈 , improve in experi-
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2013年第1期55-59,共5页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
湖北省教育厅科学研究计划资助项目(B20092905)
湖北民族学院博士科研启动基金资助项目(20100213)
关键词
降脂合剂
高脂血症
血脂谱
载脂蛋白
血液流变学
Jiangzhi mixture
Hyperlipidemia
Lipid profile
Apolipoprotein
Blood rheology
