摘要
目的:研究TP方案化疗并同步放疗治疗中晚期宫颈癌的临床疗效。方法:将2000年1月至2006年12月收治的118例中晚期宫颈癌患者分为同步放化疗组(75例)和单纯放疗组(43例)进行治疗,比较两组近期疗效、5年生存率及不良反应。结果:同步放化疗组近期有效率92.0%,单纯放疗组有效率79.1%,两组比较差异有统计学意义(P<0.05);同步放疗组5年生存率61.3%,单纯放疗组5年生存率41.9%,两组差异有统计学意义(P<0.05);两组放射性直肠炎及放射性膀胱炎发生率差异无统计学意义(P>0.05),但恶心、呕吐等消化道反应及白细胞降低等骨髓抑制发生率在同步放化疗组较单纯放疗组增高,两组差异有统计学意义(P<0.05),不良反应经积极处理后能够耐受。结论:TP方案化疗并同步放疗可显著提高中晚期宫颈癌患者的近期疗效及5年生存率,不良反应并无明显增加。
Objective： To investigate the therapeutic effect of concurrent TP chemotherapy and radiotherapy for patients with advanced cervical cancer. Methods： From Jan 2000 to Dec 2006,118 patients with advanced cervical cancer were divided into two groups： concurrent chemoradiotherapy group（75 cases） and only radiotherapy group（43 cases） in which the short term therapeutic effect, 5 year survival rate and side effects were evaluated at the end of therapy. Results： The short term response rate of in concurrent ehemoradiotherapy group and only radiotherapy group was respectively 92.0% and 79.1% in which there was significantly statistical difference between two groups（P〈0.05）. The 5 year survival rate was 61.3% in concurrent chemoradiotherapy group and 41.9% in only radiotherapy group（P〈0.05 ）. More severe toxicity was found in concurrent ehemoradiotherapy group which was tolerance after effective treatment. Conclusions： The concurrent TP chemotherapy and radiotherapy for patients with advanced cervical cancer can significandy improve short term therapeutic effect and 5 year survival without significantly increasing side effects.
出处
《甘肃医药》
2013年第2期85-87,共3页
Gansu Medical Journal
关键词
宫颈癌
化疗
放疗
同步放化疗
cervical cancer
radiotherapy
chemotherapy
concurrent chemoradiotherapy
