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miR-34家族在肿瘤及辐射损伤中的研究进展 被引量：1

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摘要 抑癌基因p53调节多种microRNA的表达,其中最典型的是miR-34家族。miR-34以p53依赖的方式诱导下游基因的表达,使细胞周期阻滞,促进细胞凋亡及衰老等。在肿瘤中恢复miR-34的表达可抑制细胞增殖,从而发挥抑癌作用。另外,在辐射损伤中miR-34异常表达以促进DNA损伤修复;增强或抑制miR-34的表达可提高肿瘤的辐射敏感性或增强正常组织的辐射抗性,以达到更好的放疗效果。本文主要综述miR-34在肿瘤中的表达情况及诊断治疗方面的最新进展,并介绍了miR-34在辐射损伤及影响辐射敏感性方面的作用。
作者 陈雪 刘建香
机构地区 中国疾病预防控制中心辐射防护与核安全医学所
出处 《癌变．畸变．突变》 CAS CSCD 2013年第1期76-78,共3页 Carcinogenesis,Teratogenesis & Mutagenesis
基金 国家自然科学基金项目(31100606)
关键词 miR-34 P53 肿瘤 辐射损伤 辐射敏感性
分类号 R730.23 [医药卫生—肿瘤]
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参考文献26

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二级参考文献27

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癌变．畸变．突变
2013年 第1期

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