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单克隆B细胞增多症与慢性淋巴细胞白血病的相关性研究

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摘要 目的观察单克隆B细胞增多症(MBL)与慢性淋巴细胞性白血病(CLL)的关系。方法调查1508例正常血细胞计数,年龄61～80岁和2002例淋巴细胞增多症(>4000/mm3)患者,应用流式细胞仪检测分析。结果正常细胞计数组中单克隆CLL表型B细胞者75例(5.0%),淋巴细胞增多症病例中280例(14.0%),在淋巴细胞增多的研究对象中,30%的患者进展为CLL,10%的患者需要化疗。随访5年间,35%的患者死亡,但死于CLL者仅6例。年龄68岁以上和低血红蛋白水平可预示死亡危险性增加。结论在一般人群中和在淋巴细胞增多患者中CLL表型的细胞,同慢性淋巴细胞白血病细胞有共同的特点。这一发现提示有CLL表型的单克隆B淋巴细胞增多者应加强监测,必要时应进行治疗。
作者 高梅玲 宁国强 赵施竹
机构地区 河南鹤壁市人民医院检验科 北京空军总医院检验科 河南省郑州市大桥医院内科
出处 《中华全科医学》 2013年第2期296-297,共2页 Chinese Journal of General Practice
关键词 慢性淋巴细胞性白血病 淋巴细胞增多症 单克隆B细胞增多症
分类号 R446.113 [医药卫生—诊断学] R733.72 [医药卫生—肿瘤]
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参考文献10

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二级参考文献26

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中华全科医学
2013年 第2期

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