摘要
目的探讨高敏肌钙蛋白Ⅰ(hs-cTnⅠ)检测在不稳定型心绞痛(UAP)患者的诊断、冠状动脉病变严重程度及短期预后判断等方面中的应用。方法 102例常规血清cTnⅠ阴性的UAP患者,冠状动脉造影前测定血清hs-cTnI水平,随访30d,记录心血管不良事件。结果 hs-cTnⅠ水平随着冠脉病变的严重程度而升高,hs-cTnⅠ水平越高,冠脉狭窄程度及病变累及血管的程度越严重,差异有统计学意义(P<0.05)。hs-cTnⅠ升高组主要心血管事件发生率明显高于hs-cTnⅠ正常组,差异有统计学意义(P<0.01)。结论 hs-cTnI水平的高低可预测冠脉病变的狭窄严重程度与病变范围,其升高提示短期预后不佳、主要心血管事件发生率增加,可作为UAP早期危险分层的一个指标。
Objective To explore the application of serum high sensitivity cardiac troponin I （hs-cTnI） detection in clinical diag- nosis, coronary artery disease severity and short-term prognostic in unstable angina pectoris（UAP） patients. Methods 102 UAP patients with cTnI negative were selected. Serum bs-cTnI was measured before coronary angiography, and was followed-up to 30 days. The main cardiovascular events was recorded. Results Serum hs-cTnI levels increased with the degree of coronary artery dis- ease. The levels of serum hs-cTnI were higher, coronary stenosis and vascular lesions were more serious（P〈0.05）. The incidence of short-term cardiovascular events in patients with elevated serum hs-cTnI was significantly higher than that of normal group（P〈 0.01）. Conclusion Serum hs-cTnI levels may predict the severity of coronary and the major cardiovascular events. It may be used as an early risk stratification in UAP.
出处
《国际检验医学杂志》
CAS
2012年第17期2049-2050,2053,共3页
International Journal of Laboratory Medicine
基金
中山市科技计划项目立项课题资助项目(20113A061)
