摘要
目的探讨利奈唑胺对血小板的影响。方法以万古霉素为对照,采用回顾性队列研究方法,收集我院2009年1月至2012年4月住院感染患者215例,其中,利奈唑胺组(观察组)102例,万古霉素组(对照组)113例。比较2组治疗前后血小板减少的发生率。结果观察组和对照组的血小板发生率分别为40.2%和8.0%;利奈唑胺组发生血小板减少的相对危险度较高[RR=6.30,95%CI(2.69～14.77),P<0.01]。结论利奈唑胺致血小板减少的发生率显著高于万古霉素,临床使用利奈唑胺时应密切监测血小板变化。
Objective To investigate the effects of linezolid on platelet and provide referrenee for clinical pharmaceutical care. Methods A retrospective cohort study was conducted compared with vancomycin. The datas of 215 inpatients with infectious diseases from January 2009 to April 2012 were collected and divided into two groups,linezolid group （102 cases） and vaneomycin group （ 113 cases）. The incidences of thrombocytopenia were analyzed. Results The incidence of thrombocytopenia in the linezolid group and vancomycin group was 40. 2% and 8.0% respectively. The relative risk （RR） of thrombocytopenia in the exposed group was 6.30（95% CI =2.69 - 14. 77）. The differences between the two groups were statistically significant （P〈 0. 01 ）. Conclusion The incidence of thromboeytopenia related to linezolid is higher than that of vancomycin. It is necessary to monitor the platelet in patients treated with linezolid.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2013年第1期68-69,72,共3页
The Chinese Journal of Clinical Pharmacology
