摘要
目的:观察丙泊酚复合小剂量芬太尼或舒芬太尼在无痛人工流产中的麻醉效果和安全性。方法:选择门诊ASAⅠ～Ⅱ级自愿接受无痛人工流产的手术患者100例,随机分为两组。即1μg/kg芬太尼复合丙泊酚组(F组50例),0.1μg/kg舒芬太尼复合丙泊酚组(S组50例)。观察并记录两组入手术室(T0)、麻醉诱导后(T1)、手术中扩宫颈时(T2)、术毕意识恢复(T3)各时点的平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO2);丙泊酚的用量、手术时间、术毕清醒时间、恶心呕吐发生率、术中镇痛及术后宫缩痛的情况。结果:两组患者麻醉前、手术中、手术结束时的BP、HR、RR、SpO2均有变化,但组间比较差异无统计学意义(P>0.05);两组的术中镇痛效果均满意,组间比较差异无统计学意义(P>0.05),但术后镇痛S组优于F组,S组术毕清醒时间短于F组,S组丙泊酚用量小于F组(P<0.05)。结论:1μg/kg芬太尼复合丙泊酚与0.1μg/kg舒芬太尼复合丙泊酚应用于无痛人工流产麻醉,两种方法均安全可靠,镇痛效果满意,但舒芬太尼复合丙泊酚术毕清醒时间更短,丙泊酚用量更少,术后对宫缩痛的抑制更好,优于芬太尼复合丙泊酚。
Objective ： To compare the efficacy and safety of propofol combined with low dose fentanyl or sufentanil on anesthesia for induced abortion. Methods ： 100 ASA Ⅰ-Ⅱ patients of early pregnancy with voluntarily induced abortion were randomized to two groups.Group F （50 cases） was anesthetized with 1 μg/kg fentanyl combined with propofol, whereas group S（50 cases）was anesthetized with 0.1μ g/kg sufentanil combined with propofol.The changes of blood pressure, heart rate, breath rate and oxygen saturation were observed during the anesthesia.The total dose of propofol, operation duration, the time for emergence, the incidence of nausea and vomiting, the intraoperative analgesia and the incidence of abdominal pain after operation were recorded.Results ： The BP, HR, RR, SpO2 changed before anesthesia, intraoperative, the end of the operation, but there was no statistically significant difference（P〉0.05） in two groups.The effect of analgesia during operation was satisfactory in both of group F and group S, the intraoperative analgesia was no different in two groups（P〉O.05）, but the effect of analgesia after operation in group S was better than that of in group F, the time for emergence in group S were shorter than that in group F, The total dose of propofol in group S were less than that in group F（P〈 O.05）.Conclusion ： Anesthesia with both 1 μ g/kg fentanyl combined with propofol and 0.1 μ g/kg sufentanil combined with propofol for induced abortion are safe and reliable, but the time for emergence in group S are shorter than that in group F.The total dose of propofol in group S are less than that in group F.and the effect of analgesia with sufentanil combined with propofol after operation is better than that of sufentanil combined with propofol, and its effects are better than propofol combined with fentanyl.
出处
《中外医学研究》
2012年第36期1-2,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
