摘要
目的分析亚临床甲状腺功能减退症(简称甲减)患者的血清内皮素(ET)、纤维蛋白原(FIB)和血脂水平的变化,从而了解它们之间的相互关系及其意义。方法选择50例亚临床甲减患者,根据促甲状腺激素(TSH)水平的不同,将其分为Ⅰa和Ⅰb两组作为观察组,另外选取30例健康体检志愿者作为对照组,分别测定并比较3组的ET、FIB、TSH和血脂水平。结果Ⅰa组和Ⅰb组的总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和FIB的水平随着TSH水平的升高而逐级升高,与对照组相比差异有统计学意义(P<0.05)。随着TSH水平的升高,高密度脂蛋白(HDL)和ET水平与对照组相比,差异无统计学意义(P>0.05)。结论 ET与亚临床甲减无明显相关性,但亚临床甲减患者血清FIB和血脂等动脉硬化危险因素明显升高,因此对亚临床甲减患者有必要采取适当的干预措施或定期随访来降低动脉粥样硬化(AS)的发病率。
Objective To analyze the levels of serum ET,FIB and blood lipids in subclinical hypothyroidism patients and to un derstand the relationship between them and its significance. Methods The clinical data of 50 patients with subclinical hypothyroid ism as observation group were divided into I a group and I b group according to the level of TSH and also selected 30 cases of healthy check-up volunteers as control group. Determined and compared the serum ET,FIB,TSH and blood lipid between observa- tion group and control group. Results With the aggravation of TSH leveI,TC,TG,LDL-C and FIB heightened step by step. The differences had statistical significance compared with control group（P〈0.05）, but with the increase of TSH level, there were no significant differences compared with control group in HDL and ET（P〉0.05）. Conclusion ET had no significant correlation with subclinical hypothyroidism. But the subclinical hypothyroidism in patients with serum FIB and blood lipid and atherosclerotic risk factors increased significantly. So it is necessary to adopt appropriate intervention measures or regular follow-up in subclinical bypo thyroidism patients to reduce the incidence of atherosclerosis.
出处
《国际检验医学杂志》
CAS
2012年第23期2828-2829,共2页
International Journal of Laboratory Medicine
基金
深圳市宝安区科技计划项目(20110535)
