摘要
长片段非编码RNA（long non—coding RNA，LncRNA）是肿瘤病理中涉及致癌及抑癌的调控通路中的重要的新型分子。LncRNA在人类许多疾病，特别是在癌症中异常表达，但其中绝大多数的生物学功能并不明确。近年来有关LncRNA的分子机制逐渐清晰，人们对发病较高的肝癌、乳腺癌、肺癌以及前列腺癌中表达差异的LncRNA的进行深入探索，也为未来肿瘤的诊断和治疗提供了非常有价值的科学依据。
Long non-coding RNA （LncRNA） is both oncogenic and tumor suppressive pathways. It was human diseases, especially in cancers. However, unknown. Recently, differentially expressed er. In this review, we highlight some recent an important molecule newly discovered in reported aberrantly expressed in a number of most of its biological function remains lncRNA has been recognized as a hallmark for canc- advances of lncRNA in cancer metastasis.
出处
《医学分子生物学杂志》
CAS
CSCD
2012年第4期292-295,共4页
Journal of Medical Molecular Biology
基金
浙汀省自然科学基金（No.Y2100681）,浙江省科技厅公益技术研究社会发展项目（No.2012C23073）
